药学研究2025，Vol.44Issue(6)：543-546,4.DOI:10.13506/j.cnki.jpr.2025.06.004
齐墩果酸二氟甲酯的合成及其抗肝纤维化作用
Synthesis of gem-difluoromethylenated oleanolic acid and its anti-hepatic fibrosis effect
摘要
Abstract
Objective To assess the protective efficacy of the novel compound difluoromethylenated oleanolic acid(DFOA)against liver fibrosis injury in mice,induced by carbon tetrachloride(CCl4).Methods To prepare DFOA and confirm its structure,84 mice were divided into normal control,liver fibrosis model,and low,medium,and high-dose DFOA groups,as well as a positive control group.Liver fibrosis was induced using CCl4,and the mice were administered drugs by gavage for 4 weeks.Serum liver function indicators(ALT,AST,ALB)were tested,and histopathological analysis of liver tis-sue was performed.Results Treatment with DFOA led to a statistically significant decrease in ALT and AST levels in mice with liver fibrosis,accompanied by a notable increase in ALB levels.Compared to the model group,DFOA-treated mice ex-hibited marked improvements in liver injury and a reduced extent of fibrosis.Conclusion DFOA emerges as a promising a-gent with a notable protective effect against CCl4-induced liver fibrosis,highlighting its potential applications in hepatopro-tection,transaminase reduction,and fibrosis antagonism.关键词
齐墩果酸/小鼠/齐墩果酸二氟甲酯/肝纤维化Key words
Oleanolic acid/Mice/Gem-difluoromethylenated oleanolic acid/Hepatic fibrosis分类
医药卫生引用本文复制引用
王娟,郑兴,张思,王冠,戴玲,于樱姿,姚旭,郑自通..齐墩果酸二氟甲酯的合成及其抗肝纤维化作用[J].药学研究,2025,44(6):543-546,4.基金项目
中国科学院有机氟化学重点实验室项目(No.2018-10) （No.2018-10）
湖南省自然科学基金项目(No.2020JJ6052、2021JJ80015) （No.2020JJ6052、2021JJ80015）
湖南省科技厅重点项目(No.2016DK2001) （No.2016DK2001）
大学生创新创业训练计划项目(No.S202310555311) （No.S202310555311）
