药学研究2025，Vol.44Issue(6)：553-558,6.DOI:10.13506/j.cnki.jpr.2025.06.006
基于替代毒理学技术的金合欢醇安全性评价
Safety evaluation of farnesol based on alternative toxicology techniques
耿雪 1孙沛霖 1魏霞 1张娟 1李水仙 1程春雷1
作者信息
- 1. 山东省食品药品检验研究院,国家药品监督管理局胶类产品质量评价重点实验室,中药标准创新与质量评价工程实验室,产业技术基础公共服务平台,山东济南 250101
- 折叠
摘要
Abstract
Objective To evaluate the safety of acacia alcohol.Methods Derek software,short time exposure test,LL-NA and DPRA were used to predict the toxicity of acacia alcohol.Results According to Derek software,farnesol was pre-dicted to be irritant/corrosive,and further according to the grading standard of LLNA,was predicted as a moderate sensitizer by Derek EC3 model with EC3 value 4.8％.The mean elimination rate of polypeptide in DPRA was 24.21％,resulting farne-sol to be judged as a moderate sensitizer.The result of LLNA displayed that farnesol can cause moderate skin irritation reac-tion,and the EC1.6 value was 2.92％,so farnesol is predicted as a moderate sensitizer.The result of short time exposure test showed no irritation or mild irritation of farnesol.Conclusion Farnesol exhibits potential skin irritation properties and a well-documented sensitization risk.关键词
小鼠局部淋巴结试验/Derek EC3/直接多肽反应结合试验/短时暴露试验Key words
LLNA/Derek EC3/DPRA/STE分类
医药卫生引用本文复制引用
耿雪,孙沛霖,魏霞,张娟,李水仙,程春雷..基于替代毒理学技术的金合欢醇安全性评价[J].药学研究,2025,44(6):553-558,6.
