药学研究2025，Vol.44Issue(6)：559-562,604,5.DOI:10.13506/j.cnki.jpr.2025.06.007
Sin-QuEChERS结合LC-MS/MS测定典型壮阳类中药材中11种非法添加药物
Detection of 11 drugs illegally added in typical aphrodisiac traditional Chinese medicine by Sin-QuEChERS combined with LC-MS/MS
摘要
Abstract
Objective To establish an LC-MS/MS method for the detection of 11 drugs illegally added in typical aph-rodisiac traditional Chinese medicine.Methods Sample was pretreated by optimized Sin-QuEChERS filtrating clean-up technology,following determined by LC-MS/MS and quantified by standard curve method.Results The linear relationships of the 11 target substances were good in the range of 2～100 ng·mL-1,and the correlation coefficients were all greater than 0.998.The limits of detection and quantitation were in the range of 0.2～2.5 μg·kg-1 and 0.5～10 μg·kg-1,respectively.Re-coveries ranged from 66.3％to 98.4％,while the RSD ranged from 0.6％to 4.2％,and the matrix effect evaluation values ranged from 0.72 to 0.97.Conclusion The method was simple to operate and has accurate results.It can effectively purify the interferences of the medicinal material matrix,and has good precision and accuracy.It is suitable for the confirmation and quantitative analysis of 11 drugs illegally added in aphrodisiac traditional Chinese medicine.关键词
Sin-QuEChERS/液相色谱-串联质谱/中药材/壮阳药/非法添加Key words
Sin-QuEChERS/LC-MS/MS/Traditional Chinese medicine/Afrodyn/Added illegally分类
医药卫生引用本文复制引用
周一冉,单梦,李正国,孔令辰,辛军红..Sin-QuEChERS结合LC-MS/MS测定典型壮阳类中药材中11种非法添加药物[J].药学研究,2025,44(6):559-562,604,5.基金项目
国家自然科学基金项目(No.82304717) （No.82304717）
济宁市重点研发计划项目(No.2022ZDZP015) （No.2022ZDZP015）
