兽类学报2025，Vol.45Issue(4)：457-467,11.DOI:10.16829/j.slxb.150989
切除肩胛间褐色脂肪组织对雌性黑线仓鼠免疫功能的影响
Effect of interscapular brown adipose tissue removal on immune func-tion in female striped hamsters
摘要
Abstract
In order to understand the effect of thermogenic capacity on immune function in animals,female striped ham-sters(Cricetulus barabensis)were randomly assigned into the warm interscapular brown adipose tissue(IBAT)sham-re-moved group(WS,n=5),the cold IBAT sham-removed group(CS,n=7),and the cold IBAT removed group(CS,n=8).IBAT removal or gradually decreased temperature had no effect on body mass and body composition.However,low temperature reduced total body fat mass.IBAT removal did not affect organ wet masses including liver,thymus,and spleen,indicating there was no trade-off between thermogenesis and immunity at organ size levels.However,gradually decreased temperature increased the wet mass of small intestine and colon,the length of small intestine and total diges-tive tract,indicating the increase of the food processing and digestive capacities to satisfy the enhancement of energy re-quirements under the condition of low temperature.IBAT removal or gradually decreased temperature had no influence on the wet mass of thymus and spleen,the maximal phytohaemagglutinin(PHA)response,as well as the number of white blood cells,lymphocytes,intermediate granulocytes,and neutrophil granulocytes,suggesting that no trade-offs re-lationship might occur between immune function and thermogenic capacity.In summary,IBAT removal or gradually de-creased temperature had no effect on immune function in striped hamsters.关键词
黑线仓鼠/褐色脂肪组织切除/免疫功能/血液学/逐渐降温Key words
Striped hamsters(Cricetulus barabensis)/Brown adipose tissue removal/Immune function/Hematology/Gradually decreased temperature分类
生物科学引用本文复制引用
徐德立,王逸,张学英,王德华..切除肩胛间褐色脂肪组织对雌性黑线仓鼠免疫功能的影响[J].兽类学报,2025,45(4):457-467,11.基金项目
国家自然科学基金(32171496,31770444) （32171496,31770444）
中国科学院动物研究所农业虫害鼠害综合治理研究国家重点实验室开放研究基金(IPM2104) （IPM2104）
