实用休克杂志（中英文）2025，Vol.9Issue(2)：75-81,86,8.
p90RSK在脓毒症内皮功能障碍与凝血紊乱中的作用
The role of p90RSK in endothelial dysfunction and coagulation regulation in sepsis
摘要
Abstract
Objective This paper reports that the inhibition of phospho-Ser380 of p90RSK can be an effective means of treating sepsis through endothelial dysfunction and coagulation regulation.Methods In vivo,mice were performed to cecal ligation and puncture(CLP)surgery to simulate a sepsis model and then assessed for endothelial function,coagulation cascades,and survival.In vitro,HUVEC cells were exposed to lipopolysaccharide(LPS)to establish cellular models of sepsis.The expression of endothelial function,coagulant factors,and signaling pathways were detected.Further-more,the ERK/p90RSK pathway was validated using FMK.Results FMK attenuates the activation of the septic coagulation cascade,suppresses the secretion of coagulation-related mediators,alleviates tissue injury,and subsequently reduces mortality in septic mice.In addition,the secretion of the phosphorylation of p90RSK in HUVEC cells exposed to LPS stimulation was attenuated by administe-ring a p90RSK inhibitor.Conclusions This study suggested that FMK may inhibit the LPS-induced triggering of the ERK/p90RSK pathway and down-regulate PAI-1 and TF expression,subsequently a-meliorating the coagulation imbalance and endothelial dysfunction in the sepsis state.关键词
脓毒症/凝血/组织因子Key words
Sepsis/Ccoagulation/Tissue factor引用本文复制引用
杨虹静,海大容,杨益雷,陈豪,谢沛瑶,杨咪娜,徐艳艳,潘景业..p90RSK在脓毒症内皮功能障碍与凝血紊乱中的作用[J].实用休克杂志（中英文）,2025,9(2):75-81,86,8.基金项目
国家自然科学基金(项目编号:82272204,82472188) （项目编号:82272204,82472188）
浙江省"尖兵""领雁"研发计划(项目编号:2023C03084) （项目编号:2023C03084）
中央引导地方科技发展资金(项目编号:2024ZY01012) （项目编号:2024ZY01012）
