实用休克杂志（中英文）2025，Vol.9Issue(2)：91-96,6.
不同液体复苏策略在脓毒性休克患者中的临床疗效研究
Comparative study on the clinical efficacy of different fluid resuscitation strategies and nursing interven-tions in patients with septic shock
摘要
Abstract
Objective To explore the clinical efficacy of different fluid resuscitation strategies and the impact of nursing interventions in patients with septic shock.Methods This study retrospec-tively analyzed 120 patients with septic shock admitted to our hospital from February 2018 to May 2021.The patients were divided into two groups based on the type of resuscitation fluid:the Ringer's Lactate group(control group)and the Hydroxyethyl Starch Sodium Chloride group(observation group),with 60 cases in each group.Hemodynamics,clinical outcomes,and complication rates fol-lowing fluid resuscitation were evaluated.From January 2022 to January 2024,a prospective study was conducted,dividing patients into four groups based on fluid resuscitation strategies and nursing interventions,to analyze the impact of different nursing interventions on resuscitation outcomes.Re-sults In the retrospective study,the observation group had significantly lower heart rate(HR)than the control group(P＜0.001),while mean arterial pressure(MAP),central venous pressure(CVP),and stroke volume index(SVI)were significantly higher(P＜0.05).However,no signifi-cant differences were observed in cardiac index(CI)or cardiac output(CO)(P=0.18).The obser-vation group also showed significantly better Acute Physiology and Chronic Health Evaluation Ⅱ(A-PACHE Ⅱ)scores,shorter mechanical ventilation times,and reduced ICU stays compared to the control group(P＜0.001).There was no significant difference in complication rates between the groups(P＞0.05).The prospective study demonstrated that the targeted nursing group showed sig-nificantly greater improvements in HR,MAP,SVI,and CO than the routine nursing group(P＜0.05)and achieved significant advantages in APACHE Ⅱ scores and ICU stay duration(P＜0.001 and P=0.004).Moreover,targeted nursing significantly reduced the incidence of complications,par-ticularly hyperlactatemia and pulmonary edema,optimizing patient outcomes.Conclusions Fluid re-suscitation strategies combined with targeted nursing interventions can significantly improve hemody-namic status,optimize clinical outcomes,and reduce complications in patients with septic shock,demonstrating substantial clinical value.关键词
液体复苏策略/脓毒性休克/临床疗效/护理干预Key words
Fluid resuscitation strategies/Septic shock/Clinical efficacy/Nursing interventions引用本文复制引用
孙婕,王立芬,吴楠楠,吴银玲..不同液体复苏策略在脓毒性休克患者中的临床疗效研究[J].实用休克杂志（中英文）,2025,9(2):91-96,6.基金项目
中国人民解放军海军军医大学第一附属医院基础研究专项(项目编号:2023PY16) （项目编号:2023PY16）
