实用医学杂志2025，Vol.41Issue(14)：2183-2190,8.DOI:10.3969/j.issn.1006-5725.2025.14.009
创伤后应激障碍患者小脑灰质髓鞘变化与认知功能的关系
Relationship between myelin changes in cerebellar gray matter and cognitive function in PTSD
摘要
Abstract
Objective To explore the differences in cerebellar gray matter myelin content and gray matter volume between patients with post-traumatic stress disorder(PTSD)and healthy controls(HC)using the ratio of T1-weighted(T1w)and T2-weighted(T2w)images and voxel-based morphometry(VBM)analysis,and to examine the correlation of these differences with cognitive function.Methods A total of 30 PTSD patients and 30 healthy controls(HC)matched for age,gender,and education level were included in this study.Cognitive function was assessed using the Montreal Cognitive Assessment(MoCA),and magnetic resonance imaging(MRI)scans were performed for both groups.Two-sample t-tests were used to analyze the group differences in cerebellar gray matter region T1w/T2w ratios and gray matter volume.Spearman partial correlation analysis was used to explore the correla-tion between the intergroup differences and cognitive function.Results Compared to the HC group,the PTSD group showed a reduced left cerebellar gray matter T1w/T2w ratio(voxel level P＜0.001,cluster level P＜0.05,GRF corrected).The areas with decreased T1w/T2w ratio in the PTSD group also exhibited reduced gray matter volume(voxel P＜0.005,cluster P＜0.05,GRF corrected).Correlation analysis revealed a positive correlation between the left cerebellar gray matter T1w/T2w ratio and the severity of cognitive impairment in the PTSD group.Conclusions The PTSD group exhibited reduced myelin content and gray matter volume in the left cerebellar gray matter region,with both myelin reduction and volume loss positively correlating with the severity of cognitive impairment.The T1w/T2w ratio provides a new perspective for studying myelination in PTSD patients.关键词
创伤后应激障碍/T1加权/T2加权/髓鞘/小脑/灰质体积/认知障碍Key words
post-traumatic stress disorder/T1w/T2w/myelin sheath/cerebellum/gray matter vol-ume/cognitive impairment分类
医药卫生引用本文复制引用
李斌,胡敏,杨罗东,张子维,胡媛媛,张桂青..创伤后应激障碍患者小脑灰质髓鞘变化与认知功能的关系[J].实用医学杂志,2025,41(14):2183-2190,8.基金项目
国家自然科学基金项目(编号:32260208) （编号:32260208）
石河子大学第一附属医院博士基金项目(编号:BS202210) （编号:BS202210）
