实用医学杂志2025，Vol.41Issue(15)：2290-2303,14.DOI:10.3969/j.issn.1006-5725.2025.15.002
非酒精性脂肪肝患者肝脏纤维化血清学测评方法的研究进展
Research progress on serum-based assessment methods for liver fibrosis in patients with non-alcoholic fatty liver disease
摘要
Abstract
Non-alcoholic fatty liver disease(NAFLD)has become a significant global public health concern,posing substantial challenges to healthcare systems worldwide.The condition is characterized by pathological changes such as hepatic steatosis,fibrosis,and cirrhosis,with the extent of liver fibrosis serving as a key determi-nant in assessing disease progression.Due to the limitations of liver biopsy in evaluating fibrosis,there has been a growing emphasis on the clinical application of non-invasive biomarkers.This article provides a comprehensive review of four widely used serological fibrosis scoring systems for assessing NAFLD-related liver fibrosis and offers guidance on model selection tailored to specific patient populations.It further explores disease-specific scoring methodologies for patients with comorbidities,population-specific evaluation strategies,combined scoring systems,and criteria for selecting prognostic models.The discussion aims to provide both theoretical insights and practical recommendations for the future implementation of serological fibrosis assessment in NAFLD management.关键词
非酒精性脂肪性肝病/肝纤维化/非侵入性检查/血清学标志物Key words
non-alcoholic fatty liver disease/hepatic fibrosis/non-invasive examination/serological markers分类
医药卫生引用本文复制引用
马雪颖,马向明..非酒精性脂肪肝患者肝脏纤维化血清学测评方法的研究进展[J].实用医学杂志,2025,41(15):2290-2303,14.基金项目
河北省医学科学研究课题计划(编号:20242051) （编号:20242051）
