天津中医药2025，Vol.42Issue(8)：963-968,6.DOI:10.11656/j.issn.1672-1519.2025.08.03
心可舒片对心肌梗死后心力衰竭合并抑郁患者的临床疗效研究
The clinical efficacy of Xinkeshu Tablets in patients with heart failure and depression following myocardial infarction
摘要
Abstract
[Objective]To evaluate the clinical efficacy of Xinkeshu Tablets in treating post-acute myocardial infarction(AMI)with heart failure and comorbid depressive symptoms.[Methods]A total of 120 patients with depression who developed heart failure after AMI were prospectively enrolled.Based on whether patients received Xinkeshu Tablets,they were divided into a treatment group(60 cases)and a control group(60 cases).The control group received conventional Western medicine treatment,while the treatment group received Xinkeshu Tablets(0.31 g per tablet,4 tablets per dose,three times daily)in addition to conventional Western medicine treatment.Both groups were treated for a period of 3 months.Pre-and post-treatment comparisons included left ventricular ejection fraction(LVEF),Minnesota living with heart failure questionnaire(MLHFQ)scores,traditional Chinese medicine syndrome scores,Hamilton depression rating scale(HAMD),and patient health questionnaire-9(PHQ-9)scores.[Results]Compared with baseline,the treatment group showed greater improvement in LVEF(P＜0.01)and greater reductions in MLHFQ scores,traditional Chinese medicine syndrome scores,HAMD scores,and PHQ-9 scores(P＜0.01).Compared with the control group,after 3 months of treatment,the treatment group exhibited greater improvement in LVEF(P＜0.01),and significant reductions in MLHFQ scores,traditional Chinese medicine syndrome scores,HAMD scores,and PHQ-9 scores(P＜0.05).[Conclusion]On the foundation of conventional Western medical treatment,the use of Xinkeshu Tablets improves chest pain,chest tightness,and depressive symptoms in patients with heart failure complicated by depression,thereby enhancing quality of life.关键词
心肌梗死后心力衰竭/抑郁状态/心可舒片/临床研究Key words
heart failure after myocardial infarction/depressive state/Xinkeshu Tablet/clinical study分类
医药卫生引用本文复制引用
绳菁煜,田霖,赵佳,李琳,高杉,王朔,于春泉..心可舒片对心肌梗死后心力衰竭合并抑郁患者的临床疗效研究[J].天津中医药,2025,42(8):963-968,6.基金项目
天津市中医药重点领域科研项目(2023006,2025002) （2023006,2025002）
天津市教委科研计划项目(2023KJ144). （2023KJ144）
