现代中西医结合杂志2025，Vol.34Issue(12)：1607-1612,1619,7.DOI:10.3969/j.issn.1008-8849.2025.12.001
基于肠道菌群-肠-肝轴探讨代谢相关脂肪性肝病痰湿质的分布及生物学基础
Distribution and biological basis of phlegm-dampness constitution in metabolic associated fatty liver disease based on the gut microbiota-gut-liver axis
摘要
Abstract
Objective It is to analyze the traditional Chinese medicine constitution status of patients with metabolic as-sociated fatty liver disease(MAFLD),and to explore the biological basis of phlegm-dampness constitution in MAFLD based on the gut microbiota-gut-liver axis,so as to provide some reference evidence for the prevention and treatment of MAFLD through constitutional intervention therapy.Methods A total of 311 cases of MAFLD patients treated in the Depart-ment of Sub-health of Dongfang Hospital of Beijing University of Chinese Medicine from January to December 2022 were se-lected as the study subjects,their constitutions were investigated by questionnaire survey,and the results of constitution i-dentification were analyzed by frequency counting,the association rules among different TCM constitutions were mined by Apriori algorithm in IBM SPSS Modeler 18.Combining the characteristics of intestinal flora of phlegm-dampness constitution patients and MAFLD patients,the biological basis of phlegm-dampness constitution with MAFLD was analyzed.Results The MAFLD patients with biased constitution were in the majority,especially those with phlegm-dampness constitution were more common,but the differences in the distribution of constitution among patients of different genders and ages were not statistically significant(all P>0.05).The majority of MAFLD patients with accompanied TCM constitutions accounted for 71.70%(223/311).In the two types of accompanied TCM constitutions,Qi depression with Qi deficiency and Qi depres-sion with phlegm-dampness were the most common,and dampness-heat constitution was closely related to phlegm-dampness constitution.Qi deficiency,phlegm dampness and Qi stagnation were the basic constitutions in 3-5 types of accompanied constitutions,and blood stasis,Yin deficiency,Qi stagnation,Yang deficiency and dampness-heat were also complicated.In the three accompanied constitutions,phlegm dampness was closely related to blood stasis and Yin deficiency,and the confidence level was 96.154%.Among the 4 types of accompanied constitutions,the correlations of Qi deficiency with Yang deficiency,Qi stagnation and Yin deficiency,and those of phlegm-dampness with blood stasis,Yang deficiency and Yin deficiency were the highest,the confidence reached100%.Among the5 types of accompanied constitutions,the corre-lations of Qi deficiency with Yang deficiency,Qi stagnation,Yin deficiency and phlegm-dampness were the highest,the confidence reached 100%.The biological basis of MAFLD patients with phlegm-dampness constitution was closely related to intestinal flora disorders.Conclusion The traditional Chinese medicine constitution of patients with MAFLD mainly were phlegm-dampness constitution,and its biological basis is closely related to the disorder of gut microbiota.Constitution regu-lation is of great value in the prevention and treatment of MAFLD.关键词
代谢相关脂肪性肝病/痰湿质/关联分析/肠道菌群Key words
metabolic associated fatty liver disease/phlegm-dampness constitution/association analysis/gut microbi-ota分类
医药卫生引用本文复制引用
郑家丞,刘洋,马重阳,杨婷,李壮,高傲,曹蕾,赵妍..基于肠道菌群-肠-肝轴探讨代谢相关脂肪性肝病痰湿质的分布及生物学基础[J].现代中西医结合杂志,2025,34(12):1607-1612,1619,7.基金项目
国家自然科学基金青年项目(82004327) （82004327）
国家中医药管理局监测统计中心深化医改中医药政策研究项目(YGZXKT2024049) （YGZXKT2024049）
北京市中医管理局中医体质辨识治未病服务项目技术规范项目(京中医财字[2019]178号) （京中医财字[2019]178号）
中央高校基本科研业务费专项资金资助项目(2023-JYB-JBQN-031) （2023-JYB-JBQN-031）
