新发传染病电子杂志2025，Vol.10Issue(3)：47-52,6.DOI:10.19871/j.cnki.xfcrbzz.2025.03.008
HIV/AIDS患者主观与客观认知障碍现状及影响因素分析
Analysis of prevalence and influencing factors of subjective cognition and objective cognitive impairment in HIV/AIDS patients
摘要
Abstract
Objective To investigate the occurrence and influencing factors of both subjective and objective cognitive impairment in HIV/AIDS patients by combining two neurocognitive assessment scales,and to provide reference for early clinical screening and personalized intervention.Method 175 patients with HIV/AIDS hospitalized in Shenzhen Third People's Hospital from May to July 2024 were selected and investigated by general data questionnaire,Montreal Cognitive Assessment Scale(MoCA)and perceptual deficit questionnaire(PDQ).Multiple linear regression and binary Logistic regression were used to analyze the factors affecting subjective and objective neurocognitive impairment.Result Among 175 HIV/AIDS patients,65 cases(37.1%)were found to have subjective cognitive decline by perception deficit questionnaire.PDQ scores were 14.0(6.0,26.0).Objective cognitive impairment was detected in 98 patients with Montreal cognitive scale,accounting for 56.0%,and MoCA score was 26.0(22.0,28.0)points.The single factor results showed that the scores of PDQ were correlated with gender,age,insomnia,sleep quality,sleep duration and medication compliance.The scores of MoCA were correlated with gender,age,marital status,payment mode,education level,residence,monthly income,waist circumference,length of hospital stay,years of antiviral treatment,number of comorbidities,and coinfection with Hepatitis C virus(HCV).The results of multiple factors showed that gender,sleep quality and medication compliance were the factors affecting subjective cognitive decline in HIV/AIDS patients.Educational attainment and coinfection with HCV were risk factors for objective cognitive impairment.Conclusion The incidence of neurocognitive impairment is high in HIV/AIDS patients.Women,those with lower education,those with HCV infection,those with poor medication compliance and those with poor sleep quality are at high-risk for cognitive impairment.Early screening and evidence-based intervention should be given to high-risk groups in order to prevent or delay the occurrence and development of neurocognitive disorders.关键词
人类免疫缺陷病毒/获得性免疫缺陷综合征/主观认知下降/认知障碍/HIV相关神经认知障碍/影响因素Key words
Human immunodeficiency virus/Acquired immune deficiency syndrome/Subjective cognitive decline/Cognitive impairment/HIV-associated neurocognitive disorders/Influencing factors分类
医药卫生引用本文复制引用
李孟君,陈敬芳,袁静,唐芳,阮淑金,孟婷,詹翠霞..HIV/AIDS患者主观与客观认知障碍现状及影响因素分析[J].新发传染病电子杂志,2025,10(3):47-52,6.基金项目
广东省高水平临床重点专科(深圳市配套建设经费)(SZGSP011) （深圳市配套建设经费）
2.深圳市重大新发突发传染病临床医学研究中心项目(LCYSSQ20220823091203007) （LCYSSQ20220823091203007）
