新发传染病电子杂志2025，Vol.10Issue(3)：72-77,6.DOI:10.19871/j.cnki.xfcrbzz.2025.03.013
幽门螺杆菌耐药性的现状、机制及应对策略
The current status,mechanisms,and coping strategies of helicobacter pylori drug resistance
摘要
Abstract
Helicobacter pylori(H.pylori)infection is a global public health issue and is closely associated with a variety of gastric diseases,including chronic gastritis,peptic ulcers,gastric cancer,and gastric mucosa-associated lymphoid tissue lymphoma.With the extensive use of antibiotics,drug resistance in H.pylori has gradually become a key factor in treatment failure.In recent years,the drug resistance rate of H.pylori has significantly increased worldwide,particularly to commonly used antibiotics such as clarithromycin,metronidazole,and levofloxacin.The mechanisms of resistance are complex and diverse,including alterations in antibiotic targets,upregulation of drug efflux pump systems,biofilm formation,and other mechanisms.To effectively address the issue of drug resistance,in addition to traditional antibiotic susceptibility testing-guided treatment,new therapeutic approaches should be explored,such as phage therapy,nanoparticle delivery of antibiotics,and vaccine development.Moreover,strategies like optimizing existing treatment regimens,extending treatment duration,and combining probiotics or traditional Chinese medicine with antibiotics have also shown certain therapeutic effects.This review article provides a comprehensive analysis of multiple relevant studies,focusing on the current status of drug resistance,mechanisms of resistance,and coping strategies.The aim is to offer reference for clinical treatment and further research.关键词
幽门螺杆菌/耐药性/耐药机制/治疗Key words
Helicobacter pylori/Drug resistance/Resistance mechanism/Treatment分类
医药卫生引用本文复制引用
樊冰,聂勇波,裴晓改,李志鹏,周明,罗漪,向琪..幽门螺杆菌耐药性的现状、机制及应对策略[J].新发传染病电子杂志,2025,10(3):72-77,6.基金项目
吴阶平医学基金会临床科研专项基金项目(320.6750.2022-06-50) （320.6750.2022-06-50）
