右江医学2025，Vol.53Issue(7)：577-582,6.DOI:10.3969/j.issn.1003-1383.2025.07.001
线粒体自噬在糖尿病心肌病中的作用及其研究进展
Role and research progress of mitophagy in diabetic cardiomyopathy
摘要
Abstract
Diabetic cardiomyopathy(DCM)is a non-ischemic,non-hypertensive myocardial disorder induced by metabolic disturbances in patients with diabetes mellitus(DM),and it significantly affects prognosis and mortality.As the central organelle for cellular energy metabolism,mitochondrial dysfunction represents a key pathological mechanism in DCM.Mitophagy,as a critical component of mitochondrial quality control,plays a dual regulatory role in DCM progression by selectively removing damaged or dys-functional mitochondria.This review systematically summarizes the molecular mechanisms of mitophagy,including ubiquitin-dependent pathways(PINK1/Parkin pathway),receptor-mediated pathways(FUNDC1,BNIP3/NIX,PHB2,etc.),and pathways mediated by TFEB/calcineurin.It also explores their roles in DCM(such as time-dependent changes in autophagy in HFD models,potential detri-mental effects of enhanced autophagy in T1DM)and synthesizes research progress on how antidiabetic drugs(empagliflozin,liraglu-tide,metformin,etc.)improve DCM through mitophagy regulation.Elucidating the regulatory mechanisms and targeted intervention strategies of mitophagy may provide novel theoretical foundations and therapeutic directions for DCM prevention and treatment.关键词
线粒体自噬/糖尿病心肌病/糖尿病/线粒体质量控制/降糖药物Key words
mitophagy/diabetic cardiomyopathy(DCM)/diabetes mellitus(DM)/mitochondrial quality control/antidiabetic drugs分类
医药卫生引用本文复制引用
于庆,胡苏,曹桂秋..线粒体自噬在糖尿病心肌病中的作用及其研究进展[J].右江医学,2025,53(7):577-582,6.基金项目
国家自然科学基金启航项目(XYDWFY-GQH-2024-03) （XYDWFY-GQH-2024-03）
省部共建中亚高发病成因与防治国家重点实验室开放课题(SKL-HIDCA-2024-18) （SKL-HIDCA-2024-18）
