右江医学2025，Vol.53Issue(7)：592-601,10.DOI:10.3969/j.issn.1003-1383.2025.07.003
基于网络药理学探讨红景天防治阿尔茨海默病的作用机制
Exploration on the mechanism of Rhodiola rosea L. in the prevention and treatment of Alzheimer's disease based on network pharmacology
摘要
Abstract
Objective To investigate the active components and mechanism of Rhodiola rosea L.in the prevention and treatment of Alzheimer's disease(AD)by network pharmacology.Methods The main effective components of Rhodiola rosea L.were collected by CNKI,and the potential targets of Rhodiola rosea L.were predicted by Swisstarget prediction.The related targets of AD were screened by Genecards,OMIM and NCBI databases.The intersection of Rhodiola rosea L.and AD targets was obtained by Venny2.1.0.The protein interaction network was obtained by using STRING database.A component-target-disease interaction network was constructed through Cytoscape3.7.2.Finally,gene ontology(GO)analysis and Kyoto encyclopedia of genes and genomes(KEGG)pathway enrichment analysis were performed via the DAVID data-base.Results From Rhodiola rosea L.,28 chemical components,846 targets and 2226 AD-related targets were identified,with a total of 119 intersecting targets between chemical components and AD.The protein interaction network center mainly involved key targets such as GAPDH,TNF,AKT1,EGFR,STAT3,MMP9,and SRC,etc.The KEGG signaling pathway analysis mainly involved HIF-1 signaling pathway,cancer signaling pathway and PI3K-Akt signaling pathway.Conclusion Rhodiola rosea L.may play a role in treating AD by acting on multiple targets and multiple signal pathways.关键词
红景天/阿尔茨海默病/网络药理学Key words
Rhodiola rosea L./Alzheimer's disease(AD)/network pharmacology分类
医药卫生引用本文复制引用
蒋坤秀,刘青,顿珠,郑红梅,梁雪兰,尕藏卓玛,索朗次仁,白玛次旦..基于网络药理学探讨红景天防治阿尔茨海默病的作用机制[J].右江医学,2025,53(7):592-601,10.基金项目
中央引导地方科技发展资金项目(XZ202102YD0027C) （XZ202102YD0027C）
四川中医药高等专科学校科研创新团队项目(红景天开发与利用研究)(TD-2022-8) （红景天开发与利用研究）
