右江医学2025，Vol.53Issue(7)：602-606,5.DOI:10.3969/j.issn.1003-1383.2025.07.004
血液代谢物与脑梗死的因果关系:一项两样本双向孟德尔随机化研究
Causal relationship between blood metabolites and cerebral infarction:a two-sample two-way Mendelian randomization study
摘要
Abstract
Objective To explore the causal relationship between blood metabolites and cerebral infarction(CI)by two-sample two-way Mendelian randomization(MR)analysis.Methods The published genome-wide association studies(GWAS)data of cerebral infarction were obtained from public database.With a GWAS containing 1400 circulating metabo-lites as an exposure indicator,SNPs which strongly related to exposure factors were selected as instrumental variables(IV).The causal relationship between 1400 blood metabolites and cerebral infarction was analyzed by R4.3.2 software.Five meth-ods—MR-Egger regression,inverse-variance weighted(IVW),weighted median,simple mode,and weighted mode—were employed to assess heterogeneity,pleiotropy,and sensitivity,thereby verifying the robustness of the results.Finally,a reverse MR analysis was performed on the obtained results.Results IVW method was used to assess causal relationship between blood metabolites and CI,and the results showed that urea(OR=0.997,95％CI:0.996-0.999)was a protec-tive factor,and the risk of CI decreased with the increase of metabolite urea.The reverse MR results showed that there was no causal relationship between the disease and the metabolites.Conclusion Urea has an inhibitory effect on cerebral infarc-tion,which may provide new ideas and new basis for the clinical treatment and scientific research of cerebral infarction in the future.关键词
代谢产物/脑梗死/孟德尔随机化/尿素Key words
metabolites/cerebral infarction(CI)/Mendelian randomization(MR)/urea分类
医药卫生引用本文复制引用
覃露,翟阳,庞兴旺,王瀚,庞延,莫智珍,肖裕翰,黎海娜,黎芳..血液代谢物与脑梗死的因果关系:一项两样本双向孟德尔随机化研究[J].右江医学,2025,53(7):602-606,5.基金项目
广西自然科学基金(2024GXNSFAA010252,2022GXNSFBA035576) （2024GXNSFAA010252,2022GXNSFBA035576）
中国博士后科学基金资助项目(2024MD753922) （2024MD753922）
2024年广西青年岐黄学者培养项目(GXQH202419) （GXQH202419）
广西中医药适宜技术开发与推广项目(GZSY22-73) （GZSY22-73）
2025年广西中医药适宜技术开发与推广项目(GZSY2025086) （GZSY2025086）
