医学新知2025，Vol.35Issue(7)：774-782,9.DOI:10.12173/j.issn.1004-5511.202411125
免疫炎症指标在子宫内膜异位症中的诊断价值
The diagnostic value of immune-inflammatory markers in endometriosis
摘要
Abstract
Objective To explore the diagnostic value of immune-inflammatory indicators in endometriosis(EMs)and to construct a prediction model.Methods Women who visited the department of health management medicine and the department of obstetrics and gynecology of the First People's Hospital of Foshan from January 2021 to June 2024 were selected as research subjects.They were divided into EMs group and Non EMs group according to the EMs diagnostic criteria,and the clinical data of the two groups were compared.The subjects were randomly divided into a training set and a validation set at a ratio of 7∶3.Univariate and multivariate Logistic regression analysis and Lasso regression were used to screen predictive variables,and a prediction model was constructed.The receiver operating characteristic curve(ROC)and its area under the curve(AUC),calibration curve,and decision curve were used to evaluate the prediction efficiency of the model.Results A total of 6,570 subjects were included,including 6,090 in the Non EMs group and 480 in the EMs group.There were 4,599 cases in the training set and 1,971 cases in the validation set.Multivariate logistic regression analysis showed that white blood cell count[OR=2.997,95％CI(1.165,7.709)],lymphocyte count[OR=6.625,95％CI(3.436,12.774)],neutrophil count[OR=3.248,95％CI(1.082,9.753)],monocyte count[OR=4.269,95％CI(1.291,14.111)],C-reactive protein[OR=7.226,95％CI(1.840,28.382)],carbohydrate antigen 125[OR=1.603,95％CI(1.112,2.311)],Carbohydrate antigen 19-9[OR=1.470,95％CI(1.091,1.980)],interleukin-18[OR=6.251,95％CI(1.698,23.015)],and tumor necrosis factor-α[OR=4.435,95％CI(1.619,12.146)]maybe the influencing factors of EMs.The prediction model finally included three variables,lymphocyte count,C-reactive protein,and tumor necrosis factor-α.ROC analysis showed that the sensitivity of the model in the training set was 78.18％,the specificity was 75.94％,and the AUC was 0.814.The sensitivity of the model in the validation set was 80.95％,the specificity was 66.29％,and the AUC was 0.786.The calibration curve showed that the predicted probability fit well with the actual probability.The clinical decision curve showed that the model could bring clinical benefits within a certain threshold range.Conclusion The prediction model constructed with three immune-inflammatory indicators of lymphocyte count,C-reactive protein and tumor necrosis factor-α has good diagnostic efficacy and can provide a reference for the early diagnosis of EMs.关键词
子宫内膜异位/免疫指标/炎症指标/淋巴细胞数/C反应蛋白/肿瘤坏死因子α/预测模型Key words
Endometriosis/Immune index/Indicators of inflammation/Lymphocyte count/C-reactive protein/Tumor necrosis factor-α/Prediction model分类
医药卫生引用本文复制引用
王飞娥,赵巧红,晏星..免疫炎症指标在子宫内膜异位症中的诊断价值[J].医学新知,2025,35(7):774-782,9.基金项目
广东省基础与应用基础研究基金项目(2021A1515111176) （2021A1515111176）
