中国临床药理学与治疗学2025，Vol.30Issue(8)：1092-1098,7.DOI:10.12092/j.issn.1009-2501.2025.08.010
环泊酚复合舒芬太尼在颅内动脉瘤栓塞术患者中抑制气管插管反应的半数有效剂量
The median effective dose of ciprofol combined with sufentanil to in-hibit tracheal intubation reaction in patients undergoing intracranial aneurysm embolization
摘要
Abstract
AIM:To investigate the median effec-tive dose of ciprofol combined with sufentanil to in-hibit tracheal intubation reaction in patients under-going intracranial aneurysm embolization.METH-ODS:Forty-five patients who underwent emboliza-tion for intracranial aneurysms were divided into two groups according to age:non-elderly group(aged 18-64 years)and elderly group(aged＞65 years).Patients in the two groups were first given intravenous ciprofol,of which the initial dose of cip-rofol was 0.4 mg/kg and sufentanil 0.3 μg/kg and rocuronium 0.6 mg/kg were respectively injected according to BIS value and modified observer's as-sessment of alertness and sedation(MOAA/S)score.Then,endotracheal intubation was defined as 3 minutes after the induction of the study drug.Dixon sequential method was adopted,and the dose of ciprofol for the next patient was deter-mined according to whether the tracheal intuba-tion reaction was positive(Positive reaction of tra-cheal intubation was defined as the patient's kino-motor reaction such as coughing during tracheal in-tubation or the increase of MAP or HR within 2 minutes after intubation was greater than 20％of the basic value).When the tracheal intubation indi-cated a positive response,the next patient was raised by one gradient,otherwise,it was lowered by one gradient until the study ended at 7 crosses.The common dose ratio of adjacent patients was 1∶1.1.The Probit probability method was used to cal-culate the 50％effective dose(ED50),95％effective dose(ED95)and the corresponding 95％confidence interval(CI)of ciprofol.Perioperative adverse reac-tions were recorded in both groups.RESULTS:In the non-elderly group,the ED50 of ciprofol inhibit-ing positive tracheal intubation reaction was 0.472 mg/kg(95％CI 0.419-0.565 mg/kg),and the ED95 was 0.567 mg/kg(95％CI 0.513-1.293 mg/kg).In the elderly group,the ED50 of ciprofol inhibiting tra-cheal intubation reaction was 0.409 mg/kg(95％CI 0.383-0.434 mg/kg)and the ED95 was 0.452 mg/kg(95％CI 0.430-0.591 mg/kg).CONCLUSION:The ED50 of ciprofol combined with sufentanil inhibiting positive tracheal intubation reaction was 0.472 mg/kg in non-elderly patients and 0.409 mg/kg in elder-ly patients.关键词
环泊酚/颅内动脉瘤/舒芬太尼/年龄/插管反应Key words
ciprofol/intracranial aneurysm/suf-entanil/age/intubation reaction分类
医药卫生引用本文复制引用
陆方舟,刘美娟,曾琼,章文斌,陆军..环泊酚复合舒芬太尼在颅内动脉瘤栓塞术患者中抑制气管插管反应的半数有效剂量[J].中国临床药理学与治疗学,2025,30(8):1092-1098,7.基金项目
江苏省重点研发计划项目(BE2022049) （BE2022049）
江苏省重点研发计划产业前瞻与关键技术项目课题(BE2022049-1) （BE2022049-1）
