中国全科医学2025，Vol.28Issue(30)：3753-3760,8.DOI:10.12114/j.issn.1007-9572.2024.0647
农村高血压人群非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值与左心室肥厚的关系研究
Relationship between Non-high-density Lipoprotein Cholesterol to High-density Lipoprotein Cholesterol Ratio and Left Ventricular Hypertrophy in a Community-based Hypertensive Population
摘要
Abstract
Background Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol(HDL-C)ratio(NHHR),a novel composite lipid index,is a potential biomarker for assessing cardiovascular disease risk.Still,its relationship with left ventricular hypertrophy(LVH)is unclear.Objectives To explore the correlation between NHHR and LVH in hypertensive patients.Methods This is a cross-sectional study based on rural areas,and a stratified whole cluster sampling method was adopted in 2004-2005,in which 7 out of 22 townships in a county in Henan Province were selected using the simple random number method,and 63 out of the 180 villages under its jurisdiction were chosen randomly,and screening was performed among the long-staying rural residents aged 40-75 years,and finally 4 551 patients with hypertension were integrated.Patients were categorized into Q1(NHHR≤2.05),Q2(2.06≤NHHR≤2.58),Q3(2.59≤NHHR≤3.20)and Q4(NHHR≥3.21)groups according to NHHR quartiles.The clinical data of the patients in the four groups were compared.Logistic regression analysis was used to explore the association between NHHR and LVH.The consistency of the associations was confirmed using subgroup analyses.Results The differences were statistically significant in the comparison of BMI,diastolic blood pressure(DBP),alanine aminotransferase(ALT),fasting blood glucose(FBG),total cholesterol(TC),triglycerides(TG),HDL-C,low-density lipoprotein cholesterol(LDL-C),serum uric acid(SUA),serum creatinine(Scr),stroke history,coronary heart disease history and diabetes history indicators in the four groups(P<0.05).In the fully adjusted model,NHHR was associated with the risk of LVH,with the probability of LVH risk in groups Q3,and Q4 compared with group Q1 being 1.346(95%CI=1.102 to 1.644,P=0.004)and 1.344(95%CI=1.053 to 1.717,P=0.018);after controlling for all covariates except grouping variables,this relationship remained significant in subgroup analyses in the subgroups of females,<60 years of age,≥60 years of age,no history of coronary artery disease,no history of stroke,and history of diabetes mellitus(P<0.05).Conclusion This study,based on hypertensive patients in rural areas and using cross-sectional studies,revealed that high levels of NHHR were independently associated with LVH in hypertensive patients.The association was stronger in women and older subgroups,suggesting that NHHR can be used to identify patients at high risk of LVH in hypertensive populations and provide a basis for stratified management of those at high risk of LVH.关键词
非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值/左心室肥厚/高血压/农村人口/横断面研究Key words
Non-HDL cholesterol to HDL cholesterol ratio/Left ventricular hypertrophy/Hypertension/Rural population/Cross-sectional studies分类
医药卫生引用本文复制引用
秦邦国,孙瑾,李曼,邱娇娇,程柏凯,朱平,王曙霞..农村高血压人群非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值与左心室肥厚的关系研究[J].中国全科医学,2025,28(30):3753-3760,8.基金项目
国家重点研发计划(2020YFC2008900) （2020YFC2008900）
