中国比较医学杂志2025，Vol.35Issue(7)：98-108,11.DOI:10.3969/j.issn.1671-7856.2025.07.010
自噬调节剂在心肌肥厚中的作用
Role of autophagy regulators in myocardial hypertrophy
摘要
Abstract
Myocardial hypertrophy is characterized by the deleterious response of the heart to various stressors,leading to an increase in cardiomyocyte size and subsequent cardiac dysfunction.Autophagy,as a catabolic degradation process necessary for maintaining cellular homeostasis,has recently become an important mechanism in relation to the development of myocardial hypertrophy.Drawing on insights from recent molecular,cellular,and pharmacological studies,this review comprehensively explores the dual roles of autophagy compounds in myocardial hypertrophy.We investigated the contribution of autophagy flux in cardiomyocytes under physiological and pathological conditions,highlighting the complex interactions among autophagy and cardiomyocyte growth,survival,and function.In addition,we discuss the potential of modulating autophagic activity using drugs for the treatment of myocardial hypertrophy and heart failure.A critical examination of established models and the exploration of new autophagy regulators will further our understanding of the complex mechanisms that control myocardial hypertrophy and facilitate the development of targeted therapies.Ongoing research is expected to elucidate the definitive role of autophagy regulators,providing insights into their therapeutic potential and implications for clinical interventions in patients with myocardial hypertrophy and related pathologies.关键词
心肌肥厚/自噬/心肌细胞/自噬调节剂/心力衰竭Key words
myocardial hypertrophy/autophagy/cardiomyocytes/autophagy regulators/heart failure分类
医药卫生引用本文复制引用
张俊,周欣雨,万娟,张鑫..自噬调节剂在心肌肥厚中的作用[J].中国比较医学杂志,2025,35(7):98-108,11.基金项目
国家自然科学基金(82300456) （82300456）
赣州市创新与转化医学技术创新中心(2022CXZX1105). （2022CXZX1105）
