中国动物传染病学报2025，Vol.33Issue(3)：19-24,6.
MBL途径在鼠冠状病毒感染中作用的探究
The Role of MBL Pathway in Murine Coronavirus Infection
摘要
Abstract
The objective of the present study was to establish a liver injury model in immunodeficiency mice by infection with Murine hepatitis virus strain-3(MHV-3)and investigation of the role of MBL pathway in the pathological process.In this study,pathological examination and serological analysis were carried out through histopathological experiment,immunohistochemistry and detection of serum alanine aminotransferase and serum inflammatory factors to compare the difference of liver injuries between wild-type mice and MBL-deficient mice.The results showed that the MBL-deficient mice suffered more severe liver injuries and inflammatory reactions post MHV-3 infection as compared with wild-type mice.These discoveries suggested that MBL alleviateds liver injuries in mice infected with mouse coronavirus,which might provide some new treatment ideas for fulminant liver failure.关键词
鼠冠状病毒/甘露糖结合凝集素/暴发性肝衰竭/补体Key words
Murine coronavirus/mannan-binding lectin/fulminant hepatic failure/complement分类
医药卫生引用本文复制引用
方盈盈,郭彦,孙世惠,韩雪莲,李敏,赵光宇,崔玉军,王原..MBL途径在鼠冠状病毒感染中作用的探究[J].中国动物传染病学报,2025,33(3):19-24,6.基金项目
国家自然科学基金(82102369) （82102369）
病原微生物生物安全国家重点实验室项目(SKLPB2101) （SKLPB2101）
