中国现代医学杂志2025，Vol.35Issue(16)：21-27,7.DOI:10.3969/j.issn.1005-8982.2025.16.004
超声成像特征及超声血流参数鉴别Luminal型与三阴型乳腺癌的价值
Value of ultrasound imaging characteristics and blood flow parameters in differentiating luminal and triple-negative breast cancer
摘要
Abstract
Objective To analyze the value of ultrasound imaging features and blood flow parameters in differentiating luminal and triple-negative breast cancer.Methods Clinical data of 46 patients with luminal breast cancer and 23 patients with triple-negative breast cancer treated at our hospital from June 2022 to May 2023 were retrospectively analyzed.Conventional ultrasound,three-dimensional grayscale imaging,and three-dimensional power Doppler imaging,as well as immunohistochemical analysis,were performed for all patients.The ultrasound imaging characteristics and blood flow parameters of the two groups were compared.The influencing factors for luminal breast cancer and the diagnostic efficacy of ultrasonic imaging features and blood flow parameters for luminal and triple-negative breast cancer were analyzed.Results The luminal-type group had a significantly higher proportion of lesions with round or oval shapes,smooth margins,and circumferential blood flow distribution compared to the triple-negative group(P＜0.05).In contrast,the proportions of lesions with posterior acoustic enhancement,well-defined borders,and convergence sign were significantly lower in the luminal-type group than in the triple-negative group(P＜0.05).The levels of MG,MP,R and VFI in the luminal-type group were all higher than those in the triple-negative group(P＜0.05).Multivariable Logistic regression analysis showed that morphology[(OR)=3.683(95％CI:1.283,10.577)],border[(OR)=8.829(95％CI:3.018,25.830)],margin[(OR)=2.910(95％CI:1.436,5.896)],convergence sign[(OR)=8.820(95％CI:1.849,42.062)],MG[(OR)=1.101(95％CI:1.010,1.200)],MP[(OR)=1.088(95％CI:1.000,1.183)],R[(OR)=6.780(95％CI:2.317,19.837)],and VFI[(OR)=16.087(95％CI:5.498,47.065)]were all influencing factors for luminal breast cancer(P＜0.05).The ROC curve analysis revealed that the area under the curve of ultrasound imaging features combined with blood flow parameters in differentiating luminal from triple-negative breast cancer was 0.967(95％CI:0.931,1.000),with the sensitivity being 97.80％(95％CI:0.892,0.993)and the specificity being 95.70％(95％CI:0.875,0.989).Conclusion Ultrasound imaging features and blood flow parameters exhibit different characteristics between luminal and triple-negative breast cancer,demonstrating good diagnostic value and providing a useful reference for the differential diagnosis of breast cancer.关键词
乳腺癌/三阴型/Luminal型/超声成像/血流参数/鉴别Key words
breast cancer/triple-negative/luminal/ultrasonic imaging/blood flow parameters/differentiation分类
医药卫生引用本文复制引用
华蕊,林俐,戴春燕,陈金丽..超声成像特征及超声血流参数鉴别Luminal型与三阴型乳腺癌的价值[J].中国现代医学杂志,2025,35(16):21-27,7.基金项目
浙江省医药卫生科技计划项目(No:2023KY179) （No:2023KY179）
