中国现代医学杂志2025，Vol.35Issue(16)：60-65,6.DOI:10.3969/j.issn.1005-8982.2025.16.010
血清PTX3、Gal-3、Hcy对急性心肌梗死患者新发房颤的预测价值
Predictive value of serum PTX3,Gal-3 and Hcy for new-onset atrial fibrillation in patients with acute myocardial infarction
摘要
Abstract
Objective To explore the predictive value of serum pentraxin 3(PTX3),galectin-3(Gal-3)and homocysteine(Hcy)for new-onset atrial fibrillation in patients with acute myocardial infarction(AMI).Methods A total of 261 patients with AMI admitted to the First People's Hospital of Chuzhou from January 2021 to December 2024 were retrospectively selected.The enzyme-linked immunosorbent assay was conducted to measure serum PTX3,Gal-3 and Hcy levels.The patients were divided into the occurrence group(52 cases)and the non-occurrence group(209 cases)according to whether new-onset atrial fibrillation occurred during hospitalization.The clinical characteristics were compared between the two groups,and multivariable Logistic regression analysis was performed to analyze the independent factors affecting new-onset atrial fibrillation.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of PTX3,Gal-3 and Hcy for new-onset atrial fibrillation.Results The age,heart rate,left atrial diameter(LAD),and PTX3,Gal-3 and Hcy levels in the occurrence group were higher than those in the non-occurrence group,and the left ventricular ejection fraction(LVEF)in the occurrence group was lower than that in the non-occurrence group(P＜0.05).The multivariable Logistic regression analysis revealed that older age[(OR)=1.441(95％CI:1.091,1.903)],higher heart rate[(OR)=1.267(95％CI:1.068,1.503)],lower LVEF levels[(OR)=0.426(95％CI:0.262,0.681)],higher PTX3 levels[(OR)=2.816(95％CI:1.567,4.376)],higher Gal-3 levels[(OR)=4.302(95％CI:1.685,4.705)],and higher Hcy levels[(OR)=4.528(95％CI:2.087,8.866)]were all risk factors for new-onset atrial fibrillation in AMI patients(P＜0.05).The ROC curve analysis showed that the sensitivities of serum PTX3,Gal-3,Hcy and the combination of the three for predicting new-onset atrial fibrillation in AMI patients were 70.30％,73.00％,78.40％and 89.20％,with the specificities being 69.10％,68.50％,73.20％and 81.90％,and the areas under the curves being 0.791,0.795,0.834,and 0.926,respectively(P＜0.05).Conclusion PTX3,Gal-3 and Hcy are independent risk factors for new-onset atrial fibrillation in patients with AMI,and their levels have certain predictive value for the occurrence of new-onset atrial fibrillation.关键词
急性心肌梗死/房颤/正五聚蛋白3/半乳糖凝集素-3/同型半胱氨酸/预测效能Key words
acute myocardial infarction/atrial fibrillation/pentraxin 3/galectin-3/homocysteine/predictive performance分类
医药卫生引用本文复制引用
李兆伟,沈童童,李峰,刘亚圆,范鲍函..血清PTX3、Gal-3、Hcy对急性心肌梗死患者新发房颤的预测价值[J].中国现代医学杂志,2025,35(16):60-65,6.基金项目
安徽省自然科学基金(No:2208085MH131) （No:2208085MH131）
安徽医科大学青年科学基金(No:2022xkj078) （No:2022xkj078）
