中国癌症防治杂志2025，Vol.17Issue(3)：257-263,7.DOI:10.3969/j.issn.1674-5671.2025.03.01
树鼩作为特殊模式动物在医学研究中的应用
Application of tree shrews as specialized model animals in medical research
摘要
Abstract
Traditional mammalian models present certain limitations in disease research.The tree shrew(Tupaia belangeri)has emerged as a promising alternative to primate experimental animals due to its genetic,anatomical,and immunological similarities to humans,as well as advantages such as small body size and low breeding costs.In the field of infectious diseases,tree shrews are capable of mimicking various viral infections,including influenza and hepatitis,thereby providing a platform for vaccine screening and the investigation of immunological mechanism.In neuroscience,tree shrews are utilized to develop models of Alzheimer's disease and brain injury,thereby facilitating studies on neuroprotection and regeneration.In cancer research,tree shrew enable the models of liver cancer,breast cancer,and other malignancies,offering insights into tumor mechanisms and supporting drug screening.Nonetheless,challenges persist in tree shrew modeling,including the need for modification experimental techniques,shortages of antibodies,imperfect breeding systems,and ethical constraints.This review explores the applications of tree shrews in medical research from multiple perspectives,including genetics,immunology,infectious diseases,neuroscience,and oncology.The aim is to provide references for promoting tree shrews as key models in precision medicine and novel drug discovery across broader fields.关键词
树鼩/动物模型/生物医学Key words
Tree shrew/Animal model/Biomedical分类
医药卫生引用本文复制引用
李科志,唐艳萍,苏建家,曹骥..树鼩作为特殊模式动物在医学研究中的应用[J].中国癌症防治杂志,2025,17(3):257-263,7.基金项目
广西自然科学基金项目(2024GXNSFAA010395) （2024GXNSFAA010395）
广西壮族自治区中青年教师基础能力提升项目(2024KY0090) （2024KY0090）
广西肿瘤分子医学研究重点实验室自主研究项目(卫健实验室2020-3) （卫健实验室2020-3）
