中国癌症防治杂志2025，Vol.17Issue(3)：305-311,7.DOI:10.3969/j.issn.1674-5671.2025.03.07
结直肠癌防治的最新进展:从精准筛查到个体化治疗
Recent advances in the prevention and treatment of colorectal cancer:From precision screening to personalized therapy
摘要
Abstract
Colorectal cancer(CRC),identified as the third most prevalent malignant tumor worldwide,has achieved substantial progress in its prevention and treatment paradigms.In the field of early detection,the implementation of artificial intelligence technology has markedly enhanced screening efficiency,addressing the limitations inherent in traditional invasive diagnostic methods.On the therapeutic front,transanal total mesorectal excision has facilitated the preservation of organ function,while total neoadjuvant therapy strategies have notably improved tumor regression and pathological downstaging in locally advanced CRC.Immunotherapy has conferred long-term survival benefits for CRC patients exhibiting deficient mismatch repair or high microsatellite instability.Additionally,novel targeted therapies have significantly elevated both the objective response rate and clinical benefit rate for patients with advanced CRC.The current landscape of CRC prevention has entered a new phase,characterized by the integration of precision surgery with multidimensional diagnostic and thera-peutic approaches.This article provides a systematic review of recent significant research advance ments in CRC,with an emphasis on innovations in early screening and diagnosis,precise prevention strategies,advancements in minimally invasive surgical techniques,optimization of neoadjuvant treatment regimens,and breakthroughs in personalized treatment for metastatic CRC prevention and treatment.The aimis to offer decision-making references for clinical practice and establish theoretical foundations for future research directions.关键词
结直肠癌/筛查诊断/新辅助治疗/个体化治疗Key words
Colorectal cancer/Screening and diagnosis/Neoadjuvant therapy/Personalized therapy分类
医药卫生引用本文复制引用
黄子桂,黄晓量,柳俊刚,莫显伟,唐卫中..结直肠癌防治的最新进展:从精准筛查到个体化治疗[J].中国癌症防治杂志,2025,17(3):305-311,7.基金项目
国家自然科学基金项目(82460610) （82460610）
广西自然科学基金项目(2025GXNSFAA069662) （2025GXNSFAA069662）
