中国癌症防治杂志2025，Vol.17Issue(3)：312-319,8.DOI:10.3969/j.issn.1674-5671.2025.03.08
RNA可变剪接在胃癌研究中的进展
Research advances in RNA alternative splicing in gastric cancer
曾广 1李福月 2张若昕 3徐望红 3刘宏亮 4魏庆义1
作者信息
- 1. 200032 上海 复旦大学公共卫生学院流行病学教研室,公共卫生安全教育部重点实验室||511462 广州 粤港澳大湾区精准医学研究院(广州)肿瘤防治研究所
- 2. 510030 广州 广州医科大学附属第一医院急诊科
- 3. 200032 上海 复旦大学公共卫生学院流行病学教研室,公共卫生安全教育部重点实验室||322000 义乌 复旦大学义乌研究院
- 4. 511462 广州 粤港澳大湾区精准医学研究院(广州)肿瘤防治研究所
- 折叠
摘要
Abstract
Gastric cancer is a significant global public health challenge,causing a substantial disease burden.RNA alternative splicing(AS)is a critical gene expression regulation mechanism prevalent in higher eukaryotes.Through differential splicing patterns during the conversion of precursor mRNA to mature mRNA,a single gene can produce multiple splicing isoforms,thereby increasing the diversity and complexity of both transcriptomes and proteomes to meet the diverse physiological needs of an organism.RNA-AS dysregulation has been found to be associated with nearly all tumor types,contributing directly or indirectly to gastric cancer initiation,progression,drug resistance,and prognosis.Additionally,RNA-AS-related genetic variations play a crucial role in gastric cancer.This article systematically reviews research advances in the regulatory mechanisms of RNA-AS,as well as the impact of its dysregulation and related genetic variantions on gastric cancer,aiming to provide novel theoretical foundation and research perspectives for both RNA-AS-related further investigations and precision medicine strategies of gastric cancer.关键词
胃癌/RNA可变剪接/剪接因子/遗传变异/生物标志物Key words
Gastric cancer/RNA-alternative splicing/Splicing factor/Genetic variation/Biomarker分类
医药卫生引用本文复制引用
曾广,李福月,张若昕,徐望红,刘宏亮,魏庆义..RNA可变剪接在胃癌研究中的进展[J].中国癌症防治杂志,2025,17(3):312-319,8.
