中国药业2025，Vol.34Issue(15)：46-51,6.DOI:10.3969/j.issn.1006-4931.2025.15.008
血清微量营养素对慢性心力衰竭因果效应的孟德尔随机化法研究
Mendelian Randomization Study of the Causal Effect of Serum Micronutrients on Chronic Heart Failure
裘齐宁 1王路敏 2章娟 3叶岩荣 1沈赟 1王春敏3
作者信息
- 1. 复旦大学附属中山医院厦门医院,福建 厦门 361015||复旦大学附属中山医院,上海 200032
- 2. 复旦大学附属中山医院,上海 200032
- 3. 复旦大学附属肿瘤医院,上海 200032
- 折叠
摘要
Abstract
Objective To establish a two-sample Mendelian randomization(MR)method for evaluating the causal effects of six serum micronutrient levels on chronic heart failure(CHF).Methods The data was sourced from the publicly available Genome-Wide Association Studies(GWAS)database in UK Biobank.Single nucleotide polymorphisms(SNPs)strongly associated with vitamin A1,vitamin B6,vitamin B12,vitamin C,vitamin D,and vitamin E were selected as instrumental variables with a threshold of P<5×10-6.Inverse-variance weighted(IVW)method was conducted as the main MR method to infer the causal relationships between the micronutrients and CHF.Results The IVW method showed that low levels of vitamin B6[OR=0.995,95%CI(0.992,0.999),P=0.006]and vitamin B12[OR=0.994,95%CI(0.989,0.999),P=0.016]were risk factors for CHF,and no heterogeneity or horizontal pleiotropy was found,indicating the results were reliable.There was no causal relationship between other exposure factors and CHF.Conclusion Higher levels of vitamin B6 and vitamin B12 can reduce the risk of CHF.关键词
孟德尔随机化法/单核苷酸多态性/微量营养素/慢性心力衰竭/维生素B6/维生素B12Key words
mendelian randomization method/single nucleotide polymorphism/micronutrients/chronic heart failure/vitamin B6/vitamin B12分类
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裘齐宁,王路敏,章娟,叶岩荣,沈赟,王春敏..血清微量营养素对慢性心力衰竭因果效应的孟德尔随机化法研究[J].中国药业,2025,34(15):46-51,6.
