中国医院用药评价与分析2025，Vol.25Issue(7)：779-785,7.DOI:10.14009/j.issn.1672-2124.2025.07.002
参苓白术胶囊"异病同治"脾虚湿阻证溃疡性结肠炎和类风湿关节炎的机制探讨
Mechanism of Shenlingbaizhu Capsule in the Treatment of Ulcerative Colitis and Rheumatoid Arthritis with Spleen Deficiency and Dampness Obstruction Syndrome Through"Homotherapy for Heteropathy"
摘要
Abstract
OBJECTIVE:To probe into the mechanism of Shenlingbaizhu capsule in the treatment of ulcerative colitis(UC)and rheumatoid arthritis(RA)with spleen deficiency and dampness obstruction syndrome through"homotherapy for heteropathy".METHODS:The rat model of spleen deficiency and dampness obstruction syndrome was established by"improper diet+excessive fatigue+high humidity environment".At the 11th week,the RA model was induced by type Ⅱ collagen;at the 12th week,the UC model was established by enema(30％ethanol 0.25 mL+0.2 mL/100 g TNBS).After successful modeling,the rats were treated with Shenlingbaizhu capsule(200,400 and 800 mg/kg).The metabolic condition,body weight,organ index,small intestinal propulsion rate,gastric emptying rate,total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)were detected.The levels of serum gastrin,motilin,tumor necrosis factor-α(TNF-α),interleukin(IL)-1β and IL-6 were determined by enzyme-linked immunosorbent assay.Hematoxylin-Eosin(HE)staining was used to observe the pathological changes in the colon and ankle joints.RESULTS:(1)Compared with UC rats with spleen deficiency and dampness obstruction syndrome,after treatment with Shenlingbaizhu capsule,the hair condition of rats was improved,becoming more lustrous and smooth;the food intake,fecal volume and activity level increased,while the liver coefficient decreased,the small intestine propulsion rate increased,the contents of serum TC,IL-6 and IL-1β decreased,the levels of serum HDL-C and gastrin increased,the occult blood was improved,the structure of the colon wall was recovered and the inflammatory infiltration was alleviated.(2)Compared with RA rats with spleen deficiency and dampness obstruction syndrome,the hair condition was improved after treatment with Shenlingbaizhu capsule,becoming more lustrous and smooth;the food intake,fecal volume and activity level increased,while the liver coefficient decreased,the thymus coefficient increased,the small intestine propulsion rate increased,the contents of serum TC,LDL-C and TNF-α decreased,the contents of serum motilin and gastrin increased,the joint swelling was improved,and the joint cavity structure was recovered,with reduced inflammatory infiltration.CONCLUSIONS:The efficacy of Shenlingbaizhu capsule in the treatment of UC and RA with spleen deficiency and dampness obstruction syndrome through"homotherapy for heteropathy"is significant,which can improve intestinal mucosal damage and arthritis in the rats,and the mechanism is related to the alleviation of inflammatory responses.关键词
脾虚湿阻证/溃疡性结肠炎/类风湿关节炎/参苓白术胶囊/炎症反应Key words
Spleen deficiency and dampness obstruction syndrome/Ulcerative colitis/Rheumatoid arthritis/Shenlingbaizhu capsule/Inflammatory response分类
医药卫生引用本文复制引用
苏祖清,卢传坚,叶泽婷,陈海明,唐斌,李彦霖,郑旭威,江涛,黄闰月,郑广娟..参苓白术胶囊"异病同治"脾虚湿阻证溃疡性结肠炎和类风湿关节炎的机制探讨[J].中国医院用药评价与分析,2025,25(7):779-785,7.基金项目
国家自然科学基金资助项目(No.U20A20397,No.U23A6012) （No.U20A20397,No.U23A6012）
省部共建中医湿证国家重点实验室专项(No.SZ2021ZZ45,No.SZ2021ZZ15) （No.SZ2021ZZ45,No.SZ2021ZZ15）
广州市科技计划项目重点研发计划(No.202206080006) （No.202206080006）
中医药治疗难治性自身免疫病传承创新团队(No.ZYYCXTD-C-202204) （No.ZYYCXTD-C-202204）
广州市科技计划项目(No.2024A03J0702,No.2024A03J0707) （No.2024A03J0702,No.2024A03J0707）
中医证候全国重点实验室项目(No.QZ2023ZZ39) （No.QZ2023ZZ39）
