中国医院用药评价与分析2025，Vol.25Issue(7)：786-790,5.DOI:10.14009/j.issn.1672-2124.2025.07.003
检测CYP1A2 rs762551基因多态性指导奥氮平治疗精神分裂症的卫生经济学价值研究
Study on Health Economic Value of CYP1A2 rs762551 Gene Polymorphism Detection in Guiding Olanzapine Treatment for Schizophrenia
摘要
Abstract
OBJECTIVE:To explore the health economic value of CYP1A2 rs762551 gene polymorphism detection in guiding olanzapine treatment in patients with schizophrenia,and provide basis for rational clinical use of olanzapine.METHODS:Clinical data of 1 000 patients with schizophrenia from Xi'an Mental Health Center were retrospectively collected,and the distribution of CYP1A2 rs762551 gene polymorphism in the patient population was analyzed.According to whether genetic testing was performed,the patients were divided into the genetic testing group and the non-genetic testing group.The therapeutic effects and occurrence of adverse drug reactions were analyzed.Furthermore,two health economics models were established to evaluate the economic costs of different treatment regimens of olanzapine.RESULTS:The PANSS scores of both groups after olanzapine treatment were significantly lower than those before treatment in this group,the differences were statistically significant(P＜0.05).However,there was no statistically significant difference in the PANSS scores between two groups before and after treatment during the same period(P＞0.05).The incidences of various adverse drug reactions and overall adverse drug reaction in the genetic testing group were lower than those in the non-genetic testing group,with statistically significant differences(P＜0.05).Hypothesis test results of Model 1 showed the individualized treatment cost and related adverse drug reaction treatment cost of olanzapine guided by CYP1A2 rs762551 gene polymorphism testing were lower than the conventional treatment regimen of olanzapine without genetic polymorphism testing.Model 2 analysis showed that the treatment cost and related adverse drug reaction treatment cost of the conventional treatment regimen of olanzapine were higher than those of the genetic testing group.CONCLUSIONS:In the clinical use of olanzapine for the treatment of schizophrenia,the CYP1A2 rs762551 gene polymorphism detection is of health and economic significance for the rational development of olanzapine treatment regimens,reducing the incidence of adverse drug reactions and promoting clinical rational drug use.关键词
奥氮平/精神分裂症/CYP1A2基因/基因多态性/卫生经济学Key words
Olanzapine/Schizophrenia/CYP1A2 gene/Gene polymorphism/Health Economics分类
医药卫生引用本文复制引用
张燕,苏艳丽,孙丽莎..检测CYP1A2 rs762551基因多态性指导奥氮平治疗精神分裂症的卫生经济学价值研究[J].中国医院用药评价与分析,2025,25(7):786-790,5.基金项目
陕西省创新能力支撑计划项目(No.2022PT-03) （No.2022PT-03）
西安市科技计划项目(No.23YXYJ0006) （No.23YXYJ0006）
