中国医院用药评价与分析2025，Vol.25Issue(7)：805-808,4.DOI:10.14009/j.issn.1672-2124.2025.07.007
柴荆方联合氯雷他定片治疗三阳合病型慢性荨麻疹的疗效观察
Observation of Chaijing Formula Combined with Loratadine Tablets in the Treatment of Chronic Urticaria(Combined Disease of Three Yang Patterns)
摘要
Abstract
OBJECTIVE:To probe into the clinical efficacy and safety of Chaijing formula combined with Loratadine tablets in the treatment of chronic urticaria(combined disease of three Yang patterns).METHODS:A total of 80 patients with chronic urticaria from Feb.2023 to Nov.2024 of Neijiang Hospital of Traditional Chinese Medicine were randomly divided into the control group and study group,with 40 cases in each group.The control group received Loratadine tablets,while the research group was given Chaijing formula on the basis of control group,with a 4-week course of treatment.Urticaria activity score,quality of life score for chronic urticaria,traditional Chinese medicine syndrome score,serum total immunoglobulin E(IgE)level,incidence of adverse drug reactions and recurrence rate were detected.RESULTS:The total effective rates of the study group and control group were respectively 82.50％(33/40)and 45.00％(18/40),the difference was statistically significant(P＜0.01).There was no statistically significant difference in the serum total IgE conversion rate,the incidence of adverse drug reactions,and the recurrence rate between two groups(P＞0.05).After 4 weeks of treatment,the overall traditional Chinese medicine syndrome scores in the study group showed a more significant improvement compared with the control group(P＜0.05),the improvement in the score of dry mouth and bitter taste was particularly notable(P＜0.01),and the score of redness and itching was significantly alleviated(P＜0.05),the differences were statistically significant.After 4 weeks of treatment,the urticaria activity scores and the quality of life score for chronic urticaria in both groups decreased compared with those before treatment,the differences were statistically significant(P＜0.01);there was no statistically significant difference between two groups after 2 weeks of treatment(P＞0.05),yet there was statistically significant difference after 4 weeks of treatment(P＜O.05),the improvement of symptoms,signs and quality of life in the study group were more significantly than the control group.CONCLUSIONS:Chaijing formula combined with Loratadine tablets can effectively alleviate the clinical symptoms of patients with the syndrome of combined disease of three Yang patterns in chronic urticaria,which is particularly significant in improving the traditional Chinese medicine syndromes such as itching,dry mouth and bitter taste,with few adverse drug reactions.关键词
柴荆方/氯雷他定片/慢性荨麻疹/三阳合病/临床观察Key words
Chaijing formula/Loratadine tablets/Chronic urticaria/Combined disease of three Yang patterns/Clinical observation分类
医药卫生引用本文复制引用
刘泓伶,曹婷,张爱靖,陈敏,丁全美,林世俊,杨琳..柴荆方联合氯雷他定片治疗三阳合病型慢性荨麻疹的疗效观察[J].中国医院用药评价与分析,2025,25(7):805-808,4.基金项目
四川省中医药管理局科学技术研究专项课题(No.2023MS243) （No.2023MS243）
