中国医院用药评价与分析2025，Vol.25Issue(7)：809-812,4.DOI:10.14009/j.issn.1672-2124.2025.07.008
加味金铃子散对2型糖尿病合并非酒精性脂肪肝患者脂代谢和血管内皮功能的影响
Effect of Modified Jinlingzi Powder on Lipid Metabolism and Vascular Endothelial Function in Patients with Type 2 Diabetes Mellitus Complicated with Non-Alcoholic Fatty Liver Disease
摘要
Abstract
OBJECTIVE:To observe the efficacy of modified Jinlingzi powder of patients with type 2 diabetes mellitus(T2DM)complicated with with non-alcoholic fatty liver disease(NAFLD),and its effects on lipid metabolism and vascular endothelial function.METHODS:A total of 100 patients with T2DM and NAFLD admitted into the hospital from Dec.2022 to Jan.2024 were extracted to be randomly divided into the control group(50 cases)and observation group(50 cases)according to the random number table method.The control group was given conventional treatment(Metformin hydrochloride tablets+Silibinin capsules),while the observation group received conventional treatment and oral administration of modified Jinlingzi powder for 12 weeks.After treatment,the clinical efficacy of two groups was compared.The primary and secondary symptom scores before and after treatment were evaluated.The blood glucose indicators[fasting glucose(FBG),2-hour postprandial glucose(2 hBG),and glycated hemoglobin(HbA1c)],liver function indicators[alanine aminotransferase(ALT),aspartate aminotransferase(AST),and gamma glutamyl transpeptidase(GGT)],blood lipid indicators[total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)]and levels of vascular active factors[endothelin-1(ET-1),nitric oxide(NO),soluble intercellular adhesion molecule-1(sICAM-1),and vascular endothelial cell adhesion molecule-1(sVCAM-1)]were detected.RESULTS:There was no statistically significant difference in various indicators between two groups before treatment(P＞0.05).After 12 weeks of continuous treatment,the primary and secondary symptom scores in both groups significantly decreased,the levels of blood glucose(FBG,2 hBG,HbA1c)and liver function indicators(ALT,AST,GGT)significantly reduced,the levels of serum TC,TG,LDL-C,ET-1,sICAM-1,and sVCAM-1 were significantly downregulated,while the levels of HDL-C and NO were significantly upregulated,with statistically significant differences(P＜0.05).Compared with the control group(78.0％,39/50),the clinical total effective rate of observation group(92.0％,46/50)was significantly higher,the difference was statistically significant(P＜0.05).Moreover,after 12 weeks of continuous treatment,the improvement in the primary and secondary symptoms,changes in blood sugar,liver function,blood lipids and vascular endothelial function of observation group were significantly better than those of control group,the differences were statistically significant(P＜0.05).CONCLUSIONS:Modified Jinlingzi powder has significant effects on patients with T2DM complicated with NAFLD,which can effectively reduce blood glucose and lipid metabolism levels,improve liver function,regulate vascular active factor levels and improve endothelial dysfunction.关键词
2型糖尿病/非酒精性脂肪肝/加味金铃子散/脂代谢/血管内皮功能Key words
Type 2 diabetes mellitus/Non-alcoholic fatty liver disease/Modified Jinlingzi powder/Lipid metabolism/Vascular endothelial function分类
医药卫生引用本文复制引用
武朝英,高若愚,刘琼..加味金铃子散对2型糖尿病合并非酒精性脂肪肝患者脂代谢和血管内皮功能的影响[J].中国医院用药评价与分析,2025,25(7):809-812,4.基金项目
河北省中医药管理局科研计划项目(No.2023386) （No.2023386）
