中国医院用药评价与分析2025，Vol.25Issue(7)：813-815,822,4.DOI:10.14009/j.issn.1672-2124.2025.07.009
厚朴温中汤中厚朴不同炮制方式对慢性胃炎患者的疗效及安全性比较
Comparison on Efficacy and Safety of Different Processing Methods of Houpo in Houpo Wenzhong Decoction in Patients with Chronic Gastritis
摘要
Abstract
OBJECTIVE:To probe into the therapeutic effects of different processing methods of Houpo Wenzhong decoction in the treatment of chronic gastritis(CG),and its impacts on inflammatory factors and gastric motility indicators.METHODS:A total of 120 patients with CG admitted into the hospital from Oct.2023 to Oct.2024 were extracted to be randomly divided into the Group A,Group B and Group C via the random number table,with 40 cases in each group.All three groups received treatment with Houpo Wenzhong decoction.The Group A was treated with Houpo Wenzhong decoction prepared by juicing fresh ginger,the Group B was given Houpo Wenzhong decoction prepared by boiling fresh ginger,and the Group C received Houpo Wenzhong decoction prepared by boiling dried ginger.The total effective rate,traditional Chinese medicine syndrome,inflammatory factor indicators,gastric motility indicators,and adverse drug reactions of three groups were compared.RESULTS:The total effective rate of group A(95.00％,38/40)was significantly higher than that of group B(80.00％,32/40)and group C(75.00％,30/40),the differences were statistically significant(P＜0.05).After treatment,the total score of traditional Chinese medicine syndrome in group A was significantly lower than that in group B and group C,while the level of gastrin was significantly higher than that in group B and group C,the levels of interleukin(IL)-6,vasoactive intestinal peptide and IL-1 β were significantly lower than those in group B and group C,the differences were statistically significant(P＜0.05).There was no statistically significant difference in the incidence of adverse drug reactions such as acid reflux and dizziness among three groups(P＞0.05).CONCLUSIONS:Houpo Wenzhong decoction with Houpo processed with ginger juice can effectively reduce gastric mucosal damage in CG patients.Juicing fresh ginger produces the best results,being more effective than processing with either boiled fresh ginger or boiled dried ginger.In clinical practice,juicing fresh ginger can be considered as the adjuvant for processing this medicinal material.关键词
慢性胃炎/厚朴温中汤/炮制/胃动力/炎症因子Key words
Chronic gastritis/Houpo Wenzhong decoction/Processing/Gastric motility/Inflammatory factors分类
医药卫生引用本文复制引用
李玉兰,李壮毅,李珊珊..厚朴温中汤中厚朴不同炮制方式对慢性胃炎患者的疗效及安全性比较[J].中国医院用药评价与分析,2025,25(7):813-815,822,4.基金项目
河北省中医药管理局河北省2025年度中医药类科学研究课题计划项目(No.2025588) （No.2025588）
