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Drugging the'undruggable'KRAS:breakthroughs,challenges,and opportunities in pancreatic cancer

Nawaz Khan Umar Raza Syed Aqib Ali Zaidi Muhadaisi Nuer Kayisaier Abudurousuli Yipaerguli Paerhati Alifeiye Aikebaier Wenting Zhou

癌症生物学与医学（英文版）2025，Vol.22Issue(7)：762-788,27.

癌症生物学与医学（英文版）2025，Vol.22Issue(7)：762-788,27.DOI:10.20892/j.issn.2095-3941.2025.0122

Drugging the'undruggable'KRAS:breakthroughs,challenges,and opportunities in pancreatic cancer

Nawaz Khan ¹Umar Raza ¹Syed Aqib Ali Zaidi ²Muhadaisi Nuer ³Kayisaier Abudurousuli ³Yipaerguli Paerhati ³Alifeiye Aikebaier ³Wenting Zhou⁴

作者信息

1. Department of Pharmacology,School of Pharmacy,Xinjiang Medical University,Urumqi 830011,China||School of Basic Medical Sciences,Shenzhen University,Shenzhen 518060,China
2. Shenzhen Key Laboratory of Anti-Aging and Regenerative Medicine,Medical School,Shenzhen University,Shenzhen 518060,China
3. Department of Pharmacology,School of Pharmacy,Xinjiang Medical University,Urumqi 830011,China
4. Department of Pharmacology,School of Pharmacy,Xinjiang Medical University,Urumqi 830011,China||Xinjiang Key Laboratory of Natural Medicines Active Components and Drug Release Technology,Urumqi 830011,China||Xinjiang Key Laboratory of Biopharmaceuticals and Medical Devices,Urumqi 830017,China||Engineering Research Center of Xinjiang and Central Asian Medicine Resources,Ministry of Education,Urumqi 830017,China
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摘要

关键词

Pancreatic cancer/KRAS mutations/KRAS inhibitors/therapy resistance/immunotherapy

Key words

Pancreatic cancer/KRAS mutations/KRAS inhibitors/therapy resistance/immunotherapy

引用本文复制引用

Nawaz Khan,Umar Raza,Syed Aqib Ali Zaidi,Muhadaisi Nuer,Kayisaier Abudurousuli,Yipaerguli Paerhati,Alifeiye Aikebaier,Wenting Zhou..Drugging the'undruggable'KRAS:breakthroughs,challenges,and opportunities in pancreatic cancer[J].癌症生物学与医学（英文版）,2025,22(7):762-788,27.

基金项目

The study was supported by the Tianshan Talents-Youth Science and Technology Innovation Talents Training Program of Xinjiang Autonomous Region(Grant No.2022TSYCCX0035),the Xinjiang Key Laboratory of Natural Medicines Active Components and Drug Release Technology(Grant No.XJDX1713),the"Fourteenth Five-Year Plan"Key Discipline Construction Project of Xinjiang Autonomous Region(2021),the Engineering Research Center of Xinjiang and Central Asian Medicine Resources,Ministry of Education(2023),and the Xinjiang Key Laboratory of Biopharmaceuticals and Medical Devices(2023). （Grant No.2022TSYCCX0035）

癌症生物学与医学（英文版）

ISSN：2095-3941

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