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GPRC5A/CXCL8/NLRP3-mediated neutrophil extracellular traps drive gemcitabine-nab-paclitaxel resistance in pancreatic adenocarcinoma

Tianyi Zhu Qianwen Yang Xiaozhe Qian Xiuqi Wu Jianchen Fang Yuli Lin Yukuan Feng Jian Gao Qing Xia

癌症生物学与医学（英文版）2025，Vol.22Issue(7)：832-853,22.

癌症生物学与医学（英文版）2025，Vol.22Issue(7)：832-853,22.DOI:10.20892/j.issn.2095-3941.2025.0040

GPRC5A/CXCL8/NLRP3-mediated neutrophil extracellular traps drive gemcitabine-nab-paclitaxel resistance in pancreatic adenocarcinoma

Tianyi Zhu ¹Qianwen Yang ¹Xiaozhe Qian ²Xiuqi Wu ¹Jianchen Fang ³Yuli Lin ⁴Yukuan Feng ⁵Jian Gao ⁶Qing Xia¹

作者信息

1. Department of Oncology,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China
2. Department of Thoracic Surgery,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China
3. Department of Pathology,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China
4. Center for Medical Research and Innovation,Shanghai Pudong Hospital,Shanghai 200030,China||Department of Immunology,Basic Medical School,Shanghai Medical College,Fudan University,Shanghai 200030,China
5. Department of Pancreatic Cancer,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Tianjin's Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin 300060,China
6. State Key Laboratory of Systems Medicine for Cancer,Shanghai Cancer Institute,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200032,China
折叠

摘要

关键词

Pancreatic ductal adenocarcinoma/GnP resistance/neutrophil extracellular traps/GPRC5A/tumor microenvironment

Key words

Pancreatic ductal adenocarcinoma/GnP resistance/neutrophil extracellular traps/GPRC5A/tumor microenvironment

引用本文复制引用

Tianyi Zhu,Qianwen Yang,Xiaozhe Qian,Xiuqi Wu,Jianchen Fang,Yuli Lin,Yukuan Feng,Jian Gao,Qing Xia..GPRC5A/CXCL8/NLRP3-mediated neutrophil extracellular traps drive gemcitabine-nab-paclitaxel resistance in pancreatic adenocarcinoma[J].癌症生物学与医学（英文版）,2025,22(7):832-853,22.

基金项目

This work was supported by the National Natural Science Foundation of China(Grant Nos.82271883 and 82073195 to Qing.Xia （）

and 82471775 and 82271800 to Yuli.Lin),the Hospital-pharma Integration Project on Innovative Achievement Translation(Grant No.SHDC2022CRD043 to Qing.Xia),the Shanghai Jiao Tong University School of Medicine Summit Program-"Research Physician"in Clinical Medicine to Qing.Xia,the Young Physician-Scientist Cultivation Program of Shanghai Immune Therapy Institute to Qing.Xia,and the Light of the Lintel-young Talents of Huangpu to Qing.Xia. （Grant No.SHDC2022CRD043 to Qing.Xia）

癌症生物学与医学（英文版）

ISSN：2095-3941

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