中国中医眼科杂志2025，Vol.35Issue(8)：730-735,6.DOI:10.13444/j.cnki.zgzyykzz.2025.08.005
基于数据挖掘探讨国家专利库中外敷中药治疗近视的用药规律
Medication Patterns of External Application of Chinese Medicines in the Treatment of Myopia:A Data Mining Analysis Based on the National Patent Database
摘要
Abstract
OBJECTIVE To explore the medication patterns of external application of Chinese medicine for the treatment of myopia using data mining techniques based on the National Patent Database of China.METHODS Patents related to externally applied Chinese medicine prescriptions for myopia were retrieved from the China Patent Publication Announcement Database up to December 31st,2023.After screening,the prescription formulas were organized and standardized using Excel software.Statistical analyses were conducted on medication frequency,Four Qi,Five Flavors,meridian tropism,and therapeutic functions.Association rule analysis was performed using SPSS Modeler 18,generating drug association rule networks based on lift>1 and ranking by support values.Hierarchical clustering of medicines with usage frequency≥35 was conducted using SPSS 20.0.RESULTS(1)A total of 243 patents involving 441 Chinese medicines were included,with 3,124 cumulative occurrences.(2)High-frequency medicines(≥30 uses):27 medicines were identified,with the top five being Chrysanthemi flos(148,4.74%),Cassiae semen(134,4.29%),Lycii fructus(93,2.97%),Borneolum syntheticum(87,2.78%),and Angelicae sinensis radix(80,2.56%).(3)Four Qi and Five Flavors,Meridian Tropism:Cold medicines were most frequently used(709 times,22.70%).Sweet flavor was the most common(811 times,25.96%).The liver meridian was the most frequently targeted(1,092 times,35.00%).(4)Therapeutic functions:Among medicines used≥10 times,the most common categories were tonifying medicines(17 types,22.67%),heat-clearing medicines(16 types,21.33%),exterior-releasing medicines(15 types,20.00%),blood-activating and stasis-resolving medicines(8 types,10.67%),and liver-calming and wind-extinguishing medicines(4 types,5.33%).(5)Association rules:The strongest medicine combinations were Cassiae semen-Chrysanthemi flos(2 medicines),Chrysanthemi flos-Lycii fructus-Cassiae semen(3 medicines),and Lycii fructus-Menthae haplocalycis herba-Cassiae semen-chrysanthemi flos(4 medicines).(6)Cluster analysis:Three functional clusters emerged:Type I(soothing liver and relieving depression,clearing liver and improving vision);Type II(tonifying kidney and liver,promoting Qi and activating blood);Type III(tonifying Qi and calming heart,stabilizing mind and enhancing intelligence).CONCLUSIONS The external application of Chinese medicine in national patents for the treatment of myopia predominantly follows therapeutic principles of clearing liver and improving vision,tonifying kidney and liver,and calming mind to enhance intelligence.Core medicines include Chrysanthemi flos,Cassiae semen,Lycii fructus,Borneolum syntheticum,Chuanxiong rhizoma,angelicae sinensis radix,and Menthae haplocalycis herba.关键词
近视/外敷中药/国家专利/用药规律Key words
myopia/external application of Chinese medicine/national patent/medication pattern分类
医药卫生引用本文复制引用
黄一择,周日龙,肖艳萍,李丽,亢一卜,廖良..基于数据挖掘探讨国家专利库中外敷中药治疗近视的用药规律[J].中国中医眼科杂志,2025,35(8):730-735,6.基金项目
国家自然科学基金项目(81973909) （81973909）
