中成药2025，Vol.47Issue(7)：2137-2144,8.DOI:10.3969/j.issn.1001-1528.2025.07.001
大黄碳酸氢钠片质量标准完善
Quality standard improvement of Dahuang Sodium Bicarbonate Tablets
摘要
Abstract
AIM To improve the quality standard for Dahuang Sodium Bicarbonate Tablets.METHODS TLC was adopted in the qualitative identification of rhein,emodin,chrysophanol,aloe-emodin,physcion and rhapontin,after which UPLC fingerprints were established,content determination of aloe emodin-8-O-β-D-glucoside,rhein-8-O-β-D-glucoside,emodin-8-O-β-D-glucoside,chrysophanol-8-O-β-D-glucoside,physcion-8-O-β-D-glucoside,aloe-emodin,rhein,emodin,chrysophanol,physcion were performed.RESULTS The clear TLC plots demonstrated good specificity.There were 20 common peaks in the fingerprints for 8 batches of samples with the similarities of more than 0.535.Ten constituents showed good linear relationships within their own ranges(r≥0.997 0),whose average recoveries were 98.7％-104.1％with the RSDs of 0.59％-2.13％,whose content ranges were 0.274 1-2.005 9,0.547 8-5.192 2,1.209 2-3.936 3,1.039 3-3.330 2,0.307 0-1.248 1,0.118 2-0.674 7,0.115 1-0.970 3,0.224 5-1.789 3,0.881 4-4.882 6,0.801 4-5.099 1 mg/g,respectively.CONCLUSION This simple and stable method can effectively control the quality of Rhei Radix et Rhizoma in Dahuang Sodium Bicarbonate Tablets.关键词
大黄碳酸氢钠片/质量标准/TLC/UPLC指纹图谱/含量测定Key words
Dahuang Sodium Bicarbonate Tablets/quality standard/TLC/UPLC fingerprints/content determination分类
医药卫生引用本文复制引用
陈景海,黄华花,杨娅俪,王莹莹,何雪姿..大黄碳酸氢钠片质量标准完善[J].中成药,2025,47(7):2137-2144,8.基金项目
厦门市自然科学基金项目(3502Z202374043) （3502Z202374043）
福建省高校人文社科研究基地传统本草文化传承研究中心(厦门医学院)开放课题(XMMC-CMC202008) （厦门医学院）
厦门医学院校级课题(K2022-09) （K2022-09）
