肿瘤药学2025，Vol.15Issue(3)：343-348,6.DOI:10.3969/j.issn.2095-1264.2025.03.07
岩藻糖基转移酶在结直肠癌中的研究进展
Progress of fucosyltransferase in colorectal cancer
摘要
Abstract
Fucosyltransferase(FUT)is a key enzyme that regulates glycosylation,and its aberrant expression is closely related to the progression and prognosis of colorectal cancer(CRC).This article systematically reviews the classification of FUTs,their expression characteristics in CRC,and their molecular mechanisms that regulate tumor development,microen-vironment remodeling,and stem cell properties through multiple signaling pathways,and discusses the potential of diagnos-tic markers and small molecule inhibitors targeting FUTs.Future research should focus on elucidating functional heteroge-neity among FUT isoforms to advance their clinical translation.关键词
岩藻糖基转移酶/糖基化/CRC/生物标志物/靶向治疗Key words
Fucosyltransferase/Glycosylation/Colorectal cancer/Biomarker/Targeted therapy分类
医药卫生引用本文复制引用
李矜姚,宋恩峰..岩藻糖基转移酶在结直肠癌中的研究进展[J].肿瘤药学,2025,15(3):343-348,6.基金项目
国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教函[2021]272号). （国中医药人教函[2021]272号）
