中医眼耳鼻喉杂志2025，Vol.15Issue(3)：148-151,4.DOI:10.3969/j.issn.1674-9006.2025.03.005
不同粒径的超声雾化器雾化鱼腥草滴眼液治疗干眼的疗效对比
Efficacy comparison of ultrasonic nebulization with different particle sizes of houttuynia cordata eye drops in the treatment of dry eye
摘要
Abstract
Objective To compare the clinical efficacy of treating mixed dry eye using ultrasonic nebulizers nebuliz-ing Houttuynia cordata eye drops with different nebulized particle sizes.Methods A total of 56 patients with mixed dry eye were enrolled and randomly divided into Group A(Muran group,27 patients)and Group B(WH-V group,29 pa-tients).Both groups were treated with 25％Houttuynia cordata eye drops atomized by the respective devices for 4 weeks,three times per week.Assessments were conducted at 2 and 4 weeks post-treatment,including the Dry Eye Questionnaire score,Ocular Surface Disease Index(OSDI),Non-Invasive Tear Film Break-Up Time(NIBUT),Schirmer I Test(SIt),Tear Meniscus Height(LTMH),and Corneal Fluorescein Staining Score(FL).Results Both groups showed significant improvements in NIBUT and OSDI at 2 and 4 weeks post-treatment(P＜0.05).Group A also demonstrated significant improvements in SIt and the Dry Eye Questionnaire score(P＜0.05).Furthermore,Group A exhibited superior efficacy in SIt(9.65±5.84 vs.5.82±4.75 in Group B)and NIBUT(8.70±3.15 vs.7.18±2.33 in Group B),with statistically significant differences(P＜0.05).Group A showed a significant increase in LTMH post-treatment,while Group B effec-tively reduced FL.Conclusion Ultrasonic nebulizers with an atomization particle size of ≤3μm are superior to traditional ultrasonic nebulizers in improving tear secretion function,prolonging tear film stability,and tear meniscus height,and can also effectively improve patients' subjective symptoms.关键词
超声雾化/干眼/雾化粒径/鱼腥草滴眼液Key words
Ultrasonic atomization/Dry eye/Aerosol particle size/Houttuynia cordata eye drops分类
医药卫生引用本文复制引用
陈思妤,邓宇轩,谭茜月,周海兵,段俊国..不同粒径的超声雾化器雾化鱼腥草滴眼液治疗干眼的疗效对比[J].中医眼耳鼻喉杂志,2025,15(3):148-151,4.基金项目
成都中医大银海眼科医院院级课题"以超声雾化器WH-V型为对照研究目然雾化熏蒸治疗仪对混合型干眼的有效性和安全性临床研究"(KY0014) （KY0014）
