基于"阳化气,阴成形"理论探讨抗肿瘤治疗相关心脏毒性的病机与治疗经验OA

Cancer therapy-related cardiotoxicity poses a severe challenge for cancer survivors.Based on the theory of"yang transforming into qi,and yin constituting form"in Huangdi Neijing,this paper systematically explores the etiology,pathogenesis,and differentiation and treatment strategies of cancer therapy-related cardiotoxicity in traditional Chinese medicine.Anti-tumor modalities,including chemotherapy,radiotherapy,targeted therapy,and immunotherapy,induce"pathogenic toxins"that disrupt the dynamic balance of qi,blood,yin,and yang in heart.The core pathogenesis can be summarized as"yang impairment leading to dysfunctional qi transforming,yin injury resulting in structural damage,and accumulation of turbid toxins triggering pathological changes".These three mechanisms intertwine and collectively underlie the complex clinical manifestations of cancer therapy-related cardiotoxicity.Accordingly,the authors establish"harmonizing yin and yang"as the overarching therapeutic principle.Centered on the pathological core of"yang impairment-yin injury-turbid toxins",the following treatment approaches are proposed:warming and strengthening yang qi to restore transformation function,nourishing yin and fortifying the foundation to stabilize physical structure,and resolving turbid toxins to unblock heart collateral stagnation.