中医肿瘤学杂志2025，Vol.7Issue(5)：22-30,9.DOI:10.19811/j.cnki.ISSN2096-6628.2025.09.004
基于真实世界数据库非小细胞肺癌术后Ⅰ～ⅢA期中医证候要素、演变规律及相关性研究
Research on Traditional Chinese Medicine Syndrome Elements,Evolution Patterns,and Correlations in Postoperative Stage Ⅰ～ⅢA Non-Small Cell Lung Cancer Based on A Real World Database
摘要
Abstract
Objective To explore the distribution and evolution patterns of traditional Chinese medicine(TCM)syndrome elements in patients with stage Ⅰto ⅢA non-small cell lung cancer after surgery.Methods An analysis of TCM syndrome elements was conducted on 1 075 hospitalized patients with postoperative stage Ⅰto ⅢA non-small cell lung cancer from January 1,2023 to March 31,2025 across 10 hospitals including Guang'anmen Hospital,China Academy of Chinese Medical Sciences.The distribution characteristics,evolution patterns,and correlations of syndrome elements were preliminarily explored.Results The distribution of single syndrome element after NSCLC surgery was mainly characterized by qi deficiency syndrome,yin deficiency syndrome,phlegm-dampness syndrome,and blood stasis syndrome.The composite syndrome elements were qi deficiency syndrome+yin deficiency syndrome,qi deficiency syndrome+phlegm-dampness syndrome+blood stasis syndrome,blood stasis syndrome+qi stagnation syndrome,qi deficiency syndrome+phlegm-dampness syndrome.After the intervention of TCM,the proportions of major syndrome factors decreased to varying degrees.Compared with females,males had lower proportions of qi deficiency syndrome and yin deficiency syndrome,and higher proportions of phlegm-dampness syndrome and blood stasis syndrome.Compared with non-smokers,those with a history of smoking had lower proportions of qi deficiency syndrome and yin deficiency syndrome,and higher proportions of phlegm-dampness syndrome and blood stasis syndrome.Adenocarcinoma showed the highest proportions of qi deficiency syndrome and yin deficiency syndrome,followed by phlegm-dampness syndrome and blood stasis syndrome.The proportions of qi deficiency syndrome and yin deficiency syndrome in squamous cell carcinoma were lower than that in adenocarcinoma,while the proportions of phlegm-dampness syndrome and blood stasis syndrome were higher than that in adenocarcinoma.Lower differentiation degree was associated with lower proportions of qi deficiency syndrome and yin deficiency syndrome,and higher proportions of phlegm-dampness syndrome and blood stasis syndrome.As the disease stage increased,the proportions of qi deficiency syndrome and yin deficiency syndrome decreased,while the proportions of phlegm-dampness syndrome,blood stasis syndrome,and heat-toxin syndrome increased.Conclusion The distribution of syndrome elements in postoperative stage Ⅰto ⅢA NSCLC patients is mainly qi deficiency syndrome,with a mixture of deficiency and excess.The distribution of single syndrome element correlates with gender,smoking history,pathological type,degree of differentiation,and pathological stage,but not with age.关键词
非小细胞肺癌/横断面研究/中医证候要素/演变规律Key words
non-small cell lung cancer/cross-sectional study/traditional Chinese medicine syndrome element/evolution pattern分类
医药卫生引用本文复制引用
李铮,贾英杰,薛维伟,樊柄杰,张美英,侯炜,王学谦,孙玲玲,焦丽静,龚红卫,姜敏,杨忠明,王巧灵,郭环宇..基于真实世界数据库非小细胞肺癌术后Ⅰ～ⅢA期中医证候要素、演变规律及相关性研究[J].中医肿瘤学杂志,2025,7(5):22-30,9.基金项目
国家自然科学基金青年科学基金(编号:81804199) （编号:81804199）
广东省中医药高质量发展传承创新提升工程专项(粤财社[2022]102号) （粤财社[2022]102号）
符文彬广东省名中医传承工作室(粤中医办函[2020]1号) （粤中医办函[2020]1号）
东莞市蓝燕红名中医传承工作室(东卫函[2023]216号). （东卫函[2023]216号）
