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Modulating mitochondrial dynamics in CMT2A:a multifaceted platform for drug discovery and evaluation

Yang Liu Chen Yan Borui Cao Dejun Kong Jiaqi Li Wenlei Li Yingjie Guo Zhongyang Yuan Yumiao Gao Yubo Zhang Ran Sui Guo Chen Xiaojiang Hao Quan Chen

Biophysics Reports2025，Vol.11Issue(3)：P.143-155,13.

Biophysics Reports2025，Vol.11Issue(3)：P.143-155,13.DOI:10.52601/bpr.2024.240037

Modulating mitochondrial dynamics in CMT2A:a multifaceted platform for drug discovery and evaluation

Yang Liu ¹Chen Yan ²Borui Cao ³Dejun Kong ¹Jiaqi Li ⁴Wenlei Li ³Yingjie Guo ⁵Zhongyang Yuan ³Yumiao Gao ⁴Yubo Zhang ⁶Ran Sui ¹Guo Chen ¹Xiaojiang Hao ²Quan Chen¹

作者信息

1. State Key Laboratory of Medicinal Chemical Biology,College of Life Sciences,Nankai University,Tianjin 300071,China Southwest United Graduate School,Kunming 650092,China
2. State Key Laboratory of Phytochemistry and Plant Resources,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China Southwest United Graduate School,Kunming 650092,China
3. State Key Laboratory of Medicinal Chemical Biology,College of Life Sciences,Nankai University,Tianjin 300071,China
4. College of Pharmacy,Nankai University,Tianjin 300071,China
5. Arc Institute,Palo Alto,CA 94304,USA
6. Medical School,Nankai University,Tianjin 300071,China
折叠

摘要

关键词

Mitofusin-2(MFN2)/Charcot-Marie-Tooth disease type 2A(CMT2A),Mitochondrial fusion,Smallmolecule compounds/Screening and evaluation platform/CMT2A neuronal system

分类

医药卫生

引用本文复制引用

Yang Liu,Chen Yan,Borui Cao,Dejun Kong,Jiaqi Li,Wenlei Li,Yingjie Guo,Zhongyang Yuan,Yumiao Gao,Yubo Zhang,Ran Sui,Guo Chen,Xiaojiang Hao,Quan Chen..Modulating mitochondrial dynamics in CMT2A:a multifaceted platform for drug discovery and evaluation[J].Biophysics Reports,2025,11(3):P.143-155,13.

基金项目

supported by the Yunnan Provincial Science and Technology Project at Southwest United Graduate School(202402AQ370001) （202402AQ370001）

the National Natural Science Foundation of China(32400569,32230046,82293683 and 92357302) （32400569,32230046,82293683 and 92357302）

the Ministry of Science and Technology of China(2021YFC2700903) （2021YFC2700903）

the Key Research and Development Project of Yunnan Province(202003AD150012) （202003AD150012）

the Key Projects of Tianjin Science and Technology(24ZXZSSS00150) （24ZXZSSS00150）

China Postdoctoral Science Foundation(2021M691666) （2021M691666）

Tianjin Natural Science Foundation(23JCQNJC01730) （23JCQNJC01730）

“the Fundamental Research Funds for the Central Universities”,Nankai University(63231199,63241207 and 63241544)。（63231199,63241207 and 63241544）

Biophysics Reports

ISSN：2364-3439

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