首页|期刊导航|Journal of Biomedical Research|Upregulated inwardly rectifying K^(+)current-mediated hypoactivity of parvalbumin interneurons underlies autismlike deficits in Bod1-deficient mice

Upregulated inwardly rectifying K^(+)current-mediated hypoactivity of parvalbumin interneurons underlies autismlike deficits in Bod1-deficient mice

Chen Li Kerui Wang Xingfeng Mao Takuya Sasaki Xiuxiu Liu Yingmei Lu

Journal of Biomedical Research2025，Vol.39Issue(4)：P.417-429,I0019,I0020,15.

Journal of Biomedical Research2025，Vol.39Issue(4)：P.417-429,I0019,I0020,15.DOI:10.7555/JBR.38.20240394

Upregulated inwardly rectifying K^(+)current-mediated hypoactivity of parvalbumin interneurons underlies autismlike deficits in Bod1-deficient mice

Chen Li ¹Kerui Wang ¹Xingfeng Mao ²Takuya Sasaki ³Xiuxiu Liu ⁴Yingmei Lu¹

作者信息

1. Key Laboratory of Modern Toxicology of Ministry of Education/School of Basic Medical Sciences,Nanjing Medical University,Nanjing,Jiangsu 211166,China
2. School of Basic Medical Sciences,Nanjing Medical University,Nanjing,Jiangsu 211166,China
3. Department of Pharmacology,Graduate School of Pharmaceutical Sciences,Tohoku University,Sendai 980-8578,Japan
4. Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases,Ministry of Education/International Joint Laboratory for Drug Target of Critical Illnesses/Key Laboratory of Cardiovascular&Cerebrovascular Medicine/School of Pharmacy,Nanjing Medical University,Nanjing,Jiangsu 211166,China
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摘要

关键词

parvalbumin neuron/biorientation defective 1/inwardly rectifying K^(+)current/autism spectrum disorder

分类

医药卫生

引用本文复制引用

Chen Li,Kerui Wang,Xingfeng Mao,Takuya Sasaki,Xiuxiu Liu,Yingmei Lu..Upregulated inwardly rectifying K^(+)current-mediated hypoactivity of parvalbumin interneurons underlies autismlike deficits in Bod1-deficient mice[J].Journal of Biomedical Research,2025,39(4):P.417-429,I0019,I0020,15.

基金项目

supported by the National Key Research and Development Program of China(Grant No.2022YFE0108600 to Y.M.L.) （Grant No.2022YFE0108600 to Y.M.L.）

the National Natural Science Foundations of China(Grant Nos.82473918 and 82104162 to X.X.L.). （Grant Nos.82473918 and 82104162 to X.X.L.）

Journal of Biomedical Research

ISSN：1674-8301

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