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Hepatic SIRT6 protects against cholestatic liver disease primarily via inhibiting bile acid synthesis

Wen Zhang Jiahui Wang Luyao Yang Yuyun Shao Hongjun Peng Longfeng Jiang Liang Sheng

Journal of Biomedical Research2025，Vol.39Issue(4)：P.340-355,I0002,I0003,18.

Journal of Biomedical Research2025，Vol.39Issue(4)：P.340-355,I0002,I0003,18.DOI:10.7555/JBR.38.20240172

Hepatic SIRT6 protects against cholestatic liver disease primarily via inhibiting bile acid synthesis

Wen Zhang ¹Jiahui Wang ¹Luyao Yang ¹Yuyun Shao ²Hongjun Peng ³Longfeng Jiang ⁴Liang Sheng¹

作者信息

1. Department of Pharmacology,School of Basic Medical Sciences,Nanjing Medical University,Nanjing,Jiangsu 211166,China
2. Endoscopy Center,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China
3. Department of Pediatrics,Nanjing Drum Tower Hospital,Clinical College of Nanjing Medical University,Nanjing,Jiangsu 210008,China
4. Department of Infectious Diseases,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China
折叠

摘要

关键词

sirtuin 6/cholestatic liver disease/oxidative stress/mitochondrial biogenesis/bile acid synthesis

分类

医药卫生

引用本文复制引用

Wen Zhang,Jiahui Wang,Luyao Yang,Yuyun Shao,Hongjun Peng,Longfeng Jiang,Liang Sheng..Hepatic SIRT6 protects against cholestatic liver disease primarily via inhibiting bile acid synthesis[J].Journal of Biomedical Research,2025,39(4):P.340-355,I0002,I0003,18.

基金项目

supported by the National Natural Science Foundation of China(Grant No.82170877). （Grant No.82170877）

Journal of Biomedical Research

ISSN：1674-8301

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