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Continuous carbon source supply is essential for high rifamycin productivity of Amycolatopsis mediterranei in nitrate-stimulated fermentation revealed by a metabolomic study

Qi Yan Zhihui Shao Chen Yang Guoping Zhao

Acta Biochimica et Biophysica Sinica2025，Vol.57Issue(5)：P.738-748,11.

Acta Biochimica et Biophysica Sinica2025，Vol.57Issue(5)：P.738-748,11.DOI:10.3724/abbs.2024245

Continuous carbon source supply is essential for high rifamycin productivity of Amycolatopsis mediterranei in nitrate-stimulated fermentation revealed by a metabolomic study

Qi Yan ¹Zhihui Shao ¹Chen Yang ²Guoping Zhao³

作者信息

1. CAS Key Laboratory of Synthetic Biology,CAS Center for Excellence in Molecular Plant Sciences,Chinese Academy of Sciences(CAS),Shanghai 200032,China
2. CAS Key Laboratory of Synthetic Biology,CAS Center for Excellence in Molecular Plant Sciences,Chinese Academy of Sciences(CAS),Shanghai 200032,China University of Chinese Academy of Sciences,Beijing 100049,China
3. CAS Key Laboratory of Synthetic Biology,CAS Center for Excellence in Molecular Plant Sciences,Chinese Academy of Sciences(CAS),Shanghai 200032,China University of Chinese Academy of Sciences,Beijing 100049,China Bio-Med Big Data Center,CAS Key Laboratory of Computational Biology,Shanghai Institute of Nutrition and Health,Chinese Academy of Sciences,Shanghai 200031,China
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摘要

关键词

Amycolatopsis mediterranei/glucose supplementation/metabolome/nitrate-stimulating effect/rifamycin SV production

分类

医药卫生

引用本文复制引用

Qi Yan,Zhihui Shao,Chen Yang,Guoping Zhao..Continuous carbon source supply is essential for high rifamycin productivity of Amycolatopsis mediterranei in nitrate-stimulated fermentation revealed by a metabolomic study[J].Acta Biochimica et Biophysica Sinica,2025,57(5):P.738-748,11.

基金项目

supported by the grants from the National Natural Science Foundation of China(Nos.31921006 and 92051106) （Nos.31921006 and 92051106）

the National Key R&D Program of China(No.2018YFA0903700). （No.2018YFA0903700）

Acta Biochimica et Biophysica Sinica

ISSN：1672-9145

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