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Daphnetin-mediated mitophagy alleviates intervertebral disc degeneration via the Nrf2/PINK1 pathway

Yiting Tu Jiaping Ren Weiyuan Fang Chencheng Zhou Binli Zhao Tianyong Hua Yiqi Chen Zhenya Chen Yongzeng Feng Haiming Jin Xiangyang Wang

Acta Biochimica et Biophysica Sinica2025，Vol.57Issue(6)：P.927-940,14.

Acta Biochimica et Biophysica Sinica2025，Vol.57Issue(6)：P.927-940,14.DOI:10.3724/abbs.2025002

Daphnetin-mediated mitophagy alleviates intervertebral disc degeneration via the Nrf2/PINK1 pathway

Yiting Tu ¹Jiaping Ren ²Weiyuan Fang ³Chencheng Zhou ³Binli Zhao ³Tianyong Hua ³Yiqi Chen ³Zhenya Chen ³Yongzeng Feng ¹Haiming Jin ¹Xiangyang Wang¹

作者信息

1. Department of Orthopaedics,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou 325000,China Key Laboratory of Orthopaedics of Zhejiang Province,Wenzhou 325000,China The Second School of Medicine,Wenzhou Medical University,Wenzhou 325000,China
2. The First School of Medicine,Wenzhou Medical University,Wenzhou 325000,China
3. The Second School of Medicine,Wenzhou Medical University,Wenzhou 325000,China
折叠

摘要

关键词

daphnetin/IDD/mitophagy/extracellular matrix/NLRP3 inflammasome/Nrf2/PINK1

分类

医药卫生

引用本文复制引用

Yiting Tu,Jiaping Ren,Weiyuan Fang,Chencheng Zhou,Binli Zhao,Tianyong Hua,Yiqi Chen,Zhenya Chen,Yongzeng Feng,Haiming Jin,Xiangyang Wang..Daphnetin-mediated mitophagy alleviates intervertebral disc degeneration via the Nrf2/PINK1 pathway[J].Acta Biochimica et Biophysica Sinica,2025,57(6):P.927-940,14.

基金项目

supported by the grants from the National Natural Science Foundation of China(Nos.82172494,82372461,and 82202757) （Nos.82172494,82372461,and 82202757）

the Basic Scientific Research Project of Wenzhou(No.Y2023034) （No.Y2023034）

the Basic Research Projects of Wenzhou Medical University(No.KYYW202310). （No.KYYW202310）

Acta Biochimica et Biophysica Sinica

ISSN：1672-9145

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