磁共振成像2025，Vol.16Issue(8)：1-5,18,6.DOI:10.12015/issn.1674-8034.2025.08.001
双侧突发感音神经性耳聋的脑功能梯度变化与焦虑-抑郁样情绪障碍的关系研究
The relationship between the abnormality of functional gradient and anxiety-depression disorders in patients with bilateral sudden sensorineural hearing loss
摘要
Abstract
Objective:Sudden sensorineural hearing loss is one of the otologic emergency diseases which often induces anxiety-depression like emotional impairments.But how sudden sensorineural hearing loss promotes the occurrence of emotional abnormalities is unclear.This study used brain functional gradient technique to explore the relationship between sudden sensorineural hearing loss and emotional impairments.Materials and Methods:We evaluated hearing,multi-dimensional neural scales,and resting-state brain function gradients in 44 patients with sudden sensorineural hearing loss and 40 healthy controls.Functional connectivity gradients were used to identify alterations in cortical connectivity gradients induced by sudden bilateral sensorineural hearing loss.Statistical parametric mapping 12(SPM12)was used to process functional magnetic resonance imaging(fMRI)data,and Pearson's correlation was used to calculate the correlation between fMRI data and anxiety-depression like emotional impairments based on statistical package for the social sciences 22.0(SPSS 22.0)software.Results:Patients with sudden sensorineural hearing loss and healthy controls were well matched for age,gender and education level.The mean hearing thresholds of both ears in patients were significantly higher than healthy controls.The scores of anxiety and depression scales were significantly higher in patients with sudden sensorineural hearing loss.The results showed no significant difference in the primary gradient between the two groups.At the network level,patients with sudden sensorineural hearing loss showed no significant difference in the primary gradient.However,at the nodal level,increased gradient was observed in the left precuneus,while decreased gradients were observed in the left,right calcarine fissure and surrounding cortex,right parahippocampal gyrus and left medial superior frontal gyrus(P<0.001).Moreover,there was a negative correlation between anxiety and the gradient of calcarine fissure and surrounding cortex in patients with sudden sensorineural hearing loss(r=-0.413,P=0.005).Conclusions:The functional gradient changes of brain regions in patients with sudden sensorineural hearing loss may help to clarify the neuropathological basis of emotional impairments in patients with sudden sensorineural hearing loss.关键词
突发感音神经性耳聋/神经影像/磁共振成像/功能梯度/焦虑/抑郁Key words
sudden sensorineural hearing loss/neural imaging/magnetic resonance imaging/functional gradient/anxiety/depression分类
医药卫生引用本文复制引用
朱海雪,李彪,方子淮,冯源,殷信道,徐晓敏..双侧突发感音神经性耳聋的脑功能梯度变化与焦虑-抑郁样情绪障碍的关系研究[J].磁共振成像,2025,16(8):1-5,18,6.基金项目
National Natural Science Foundation of China(No.82302162). 国家自然科学基金项目(编号:82302162) （No.82302162）
