磁共振成像2025，Vol.16Issue(8)：6-12,7.DOI:10.12015/issn.1674-8034.2025.08.002
鼻咽癌患者放疗期间海马亚区体积变化的MRI纵向评估
MRI-based longitudinal assessment of hippocampal subregion volume changes during radiotherapy in nasopharyngeal carcinoma patients
摘要
Abstract
Objective:To investigate the changes in hippocampal subregion volumes in nasopharyngeal carcinoma(NPC)patients during radiotherapy and assess their correlation with radiation dose.Materials and Methods:This study was a prospective longitudinal study that enrolled 41 patients with newly diagnosed NPC between March 2019 and April 2025.Brain MRI scans were performed using a 3.0 T scanner at three time points:pre-radiotherapy(1 to 2 days before treatment),mid-radiotherapy(19 to 20 days after treatment initiation),and post-radiotherapy(1 to 2 days after treatment completion).Hippocampal subregions were automatically segmented using FreeSurfer 7.3 software,and volume changes were assessed using a linear mixed model.Pearson correlation analysis was then conducted to explore the relationship between hippocampal volume changes and radiation dose.Results:Compared to pre-radiotherapy,during the mid-radiotherapy period,the volumes of bilateral whole hippocampus,presubiculum,cornu ammonis 1(CA1),CA3,CA4,granule cell-molecular layer-dentate gyrus(GC-ML-DG),molecular layer,hippocampal amygdala transition area(HATA),and right subiculum were significantly reduced(family-wise error,FWE correction,P<0.05).After radiotherapy,except for the left HATA and right presubiculum,the volumes of other hippocampal subregions continued to decrease significantly,and the volume of the right fimbria hippocampi also decreased(FWE correction,P<0.05).The volume change in the left hippocampal tail was significantly negatively correlated with the left hippocampal radiation dose(r=-0.555).All results were corrected for FWE using the Bonferroni method,with the significance level set at a corrected p-value of<0.05.Conclusions:During radiotherapy,the volumes of several hippocampal subregions in NPC patients significantly decreased.Furthermore,after radiotherapy,the volume change in the left hippocampal tail was significantly negatively correlated with the radiation dose to the left hippocampus,indicating that the radiation dose may influence the volume change in this region.关键词
头颈部肿瘤/鼻咽癌/放疗/海马亚区/剂量-效应关系/磁共振成像Key words
head and neck neoplasms/nasopharyngeal carcinoma/radiotherapy/hippocampal subregions/dose-response relationship/magnetic resonance imaging分类
医药卫生引用本文复制引用
董创微,刘锦,操纵,周燕飞,杨立状,余永强,李海..鼻咽癌患者放疗期间海马亚区体积变化的MRI纵向评估[J].磁共振成像,2025,16(8):6-12,7.基金项目
National Natural Science Foundation of China General Program(No.82371931). 国家自然科学基金面上项目(编号:82371931) （No.82371931）
