磁共振成像2025，Vol.16Issue(8)：13-18,6.DOI:10.12015/issn.1674-8034.2025.08.003
基于DTI技术对帕金森病冻结步态患者黑质和岛叶的脑微结构变化的初步研究
A preliminary study based on diffusion tensor imaging in brain microstructure of substantia nigra and insular leaf of Parkinson's disease patients with frozen gait
摘要
Abstract
Objective:Diffusion tensor imaging(DTI)technique was used to investigate the changes of brain microstructure of substantia nigra and insula in patients with frozen gait of Parkinson's disease patients with frozen gait(PD-FOG).Materials and Methods:Thirty-five cases of PD-FOG patients were included as the case group,and twenty-four healthy control(HC)were included as the control group.All patients underwent scans of DTI,and fractional anisotropy(FA)images were obtained.The FA values in the substantia nigra and insula regions were measured separately,and the differences between the case group and the control group were compared.The results showed that the bilateral substantia nigra and insula FA values of the PD-FOG group were significantly different from those of the HC group(P<0.05).The area under the curve(AUC)of the receiver operating characteristic(ROC)curve of the left insula FA value in the PD-FOG group was the largest,followed by the right substantia nigra FA value,the left substantia nigra A value,the right insula A value,with AUC values of 0.849,0.812,0.789,and 0.657,respectively.The correlation analysis between the FA values of the substantia nigra and insula and the Unified Parkinson's Disease Rating Scale(UPDRS)score showed that the right substantia nigra FA value(r=-0.693,P=0.005),the left substantia nigra FA value(r=-0.638,P=0.014),and the left insula FA value(r=-0.516,P=0.014)were negatively correlated with the UPDRS score,while the right insula FA value was not significantly correlated with the UPDRS score.Conclusions:DTI not only reflects the brain microstructural variation between the insula regions and substantia nigra of patients with PD and freezing gait,but also it can reveal the correlation between FA values and the UPDRS score scale,providing clinical assistance for the prevention and intervention of freezing gait in PD patients.关键词
帕金森病/冻结步态/磁共振成像/扩散张量成像/黑质/岛叶/各向异性分数Key words
Parkinson's disease/frozen gait/magnetic resonance imaging/diffusion tensor imaging/substantia nigra/insular leaf/fractional anisotropy分类
医药卫生引用本文复制引用
臧任丽,王红,潘伟,叶丽丽,丰一,韦玉新,郑晓林..基于DTI技术对帕金森病冻结步态患者黑质和岛叶的脑微结构变化的初步研究[J].磁共振成像,2025,16(8):13-18,6.基金项目
Medical Research Fund of Guangdong(No.A2024514). 广东省医学科研基金立项项目(编号:A2024514) （No.A2024514）
