磁共振成像2025，Vol.16Issue(8)：19-24,6.DOI:10.12015/issn.1674-8034.2025.08.004
QSM和DTI联合应用探讨单侧大脑中动脉供血区缺血后铁沉积对脑灰质核团微结构变化的影响
The combined application of QSM and DTI to investigate the impact of iron deposition on microstructural changes in gray matter nuclei following ischemia in the unilateral middle cerebral artery territory
摘要
Abstract
Objective:This study employed quantitative susceptibility mapping(QSM)and diffusion tensor imaging(DTI)to measure alterations in iron content and microstructural integrity within the gray matter nuclei following ischemia in the middle cerebral artery(MCA)territory.Furthermore,the potential correlations between these changes were analyzed.Materials and Methods:Thirty-one patients with severe unilateral MCA stenosis or occlusion were selected for QSM,DTI,magnetic resonance arterial spin labeling(ASL)and routine MRI scans.In patients with ASL prompted ischemia,the magnetic susceptibility value(MSV),mean diffusion(MD)values and fractionalisotropy(FA)values of the affected and healthy caudate nucleus,globus pallidus,putamen,red nucleus and substantia nigra were measured respectively.Paired sample t-tests were utilized to compare the differences in these parameters between the gray matter nuclei on the two sides.Additionally,the correlations between the susceptibility values and DTI parameter values in the affected nuclei were analyzed.Results:The nucleus MSV on the affected side of the 31 patients were all higher than the contralateral side,and there was no statistically significant difference in MSV on both sides of the red nucleus(P>0.05),and the MSV differences on the other nucleus(P<0.05).Both the MD and FA values of the affected nucleus were statistically significant compared with the opposite side(P<0.05).The FA values of the caudate nucleus,putamen and substantia nigra were positively correlated with MSV(r=0.438,0.710 and 0.394,P values were all<0.05);the MD values of the caudate nucleus and putamen were negatively correlated with MSV(r=-0.417 and-0.593,P<0.05).Conclusions:Following unilateral MCA territory ischemia,abnormal iron deposition and microstructural alterations may occur in multiple gray matter nuclei of the brain.Notably,a strong correlation exists between abnormal iron deposition and microstructural changes in the putamen.关键词
缺血性脑卒中/大脑中动脉重度狭窄或闭塞/定量磁敏感图/扩散张量成像/磁共振成像/灰质核团Key words
ischemic stroke/severe stenosis or occlusion of the middle cerebral artery/quantitative susceptibility mapping/diffusion tensor imaging/magnetic resonance imaging/gray matter nuclei分类
医药卫生引用本文复制引用
郭晓琳,宋彦澄,刘凤海,康立清,王潇玉..QSM和DTI联合应用探讨单侧大脑中动脉供血区缺血后铁沉积对脑灰质核团微结构变化的影响[J].磁共振成像,2025,16(8):19-24,6.基金项目
2024 Hebei Provincial Medical Science Research Project(No.20240870). 2024年度河北省医学科学研究课题计划项目(编号:20240870) （No.20240870）
