磁共振成像2025，Vol.16Issue(8)：58-64,7.DOI:10.12015/issn.1674-8034.2025.08.009
集成MRI直方图特征联合淋巴结短径在诊断鼻咽癌淋巴结转移中的价值
Value of synthetic MRI based histogram features combined with short axis in diagnosis of lymph node metastasis in nasopharyngeal carcinoma
摘要
Abstract
Objective:To explore the value of synthetic MRI(SyMRI)based histogram analysis combined with short axis in diagnosing cervical lymph nodes metastasis(LNM)of nasopharyngeal carcinoma(NPC).Materials and Methods:This study retrospectively analyzed 53 newly diagnosed NPC patients,and 377 cervical lymph nodes(LNs)with a short axis≥4 mm(metastatic LNs:297,non-metastatic LNs:80).The nodes were randomly stratified into training(metastatic LNs:208,non-metastatic LNs:56)and test groups(metastatic LNs:89,non-metastatic LNs:24)at a 7∶3 ratio.Histogram parameters were extracted from T1,T2,and proton density(PD)maps of SyMRI and short axis was recorded for each LN.The areas under the curve(AUCs)of all histogram parameters were compared,and Spearman correlation coefficients(SCCs)between parameters were calculated.Parameters with higher diagnostic efficiency(AUC≥0.617)and lower correlation(SCC<0.8)were incorporated into logistic regression analysis for model construction.Receiver operating characteristic curve(ROC),area under the curve(AUC)and DeLong test were used to evaluate the performance of SyMRI model,size model and combined model in the diagnosis of cervical LNs.Then the nomogram and calibration curves were constructed.Results:The SyMRI model,constructed using the T1-10th percentile,T1-variance,PD-10th percentile,and PD-minimum,achieved AUCs of 0.895(training group)and 0.903(test group),which were significantly higher than those of the short-axis model(AUCs:0.824 and 0.797,respectively;both P<0.05).The combined model demonstrated the highest diagnostic efficiency,with AUCs of 0.941(training group)and 0.938(test group),significantly outperforming both individual models(both P<0.05).Conclusions:SyMRI model based on histogram parameters can effectively differentiate metastatic from non-metastatic LNs,and the diagnostic performance improved further when combined with the short axis of nodes.关键词
鼻咽癌/淋巴结转移/磁共振成像/集成磁共振成像/直方图分析/鉴别诊断Key words
nasopharyngeal carcinoma/lymph node metastasis/magnetic resonance imaging/synthetic magnetic resonance imaging/histogram analysis/differential diagnosis分类
医药卫生引用本文复制引用
魏浩然,杨凡,李晓璐,余小多,李琳,赵燕风,林蒙,赵心明..集成MRI直方图特征联合淋巴结短径在诊断鼻咽癌淋巴结转移中的价值[J].磁共振成像,2025,16(8):58-64,7.基金项目
Beijing Hope Run Special Fund of Cancer Foundation of China(No.LC2022A23). 中国癌症基金会北京希望马拉松专项基金(编号:LC2022A23) （No.LC2022A23）
