湖南中医杂志2025，Vol.41Issue(7)：15-20,6.DOI:10.16808/j.cnki.issn1003-7705.2025.07.004
参麦注射液对非小细胞肺癌生存期影响的回顾性研究
Effect of Shenmai injection on the survival time of non-small cell lung cancer:A retrospective study
摘要
Abstract
Objective:To investigate the effect of Shenmai injection on the survival time of non-small cell lung cancer(NSCLC).Methods:A retrospective study was performed for the death cases of NSCLC meeting related criteria in Yangzhong from 2020 to 2022,and according to the treatment modality,the patients were divided into control group with 69 patients(Western medicine treatment alone)and Shenmai group with 127 patients(Shen-mai injection in addition to Western medicine treatment).After propensity score matching(PSM),there were 47 patients in each group.The Cox regression model was used to investigate the influencing factors for survival time,and the Kaplan-Meier analysis and the log-rank test were used for comparison of overall survival(OS)between the two groups before and after PSM.Results:Combined treatment with Shenmai injection,chemotherapy,and targeted therapy were independent protective factors for patients with lung cancer.Compared with the control group,Shen-mai injection significantly prolonged median OS(P＜0.05),and for stage Ⅳ NSCLC patients with a survival time of＜3 years,Shenmai injection combined with immunotherapy and sodium cantharidate could prolong survival time.Con-clusion:Shenmai injection combined with Western medicine treatment can prolong the OS of patients,with more sig-nificant benefits for advanced NSCLC when combined with immunotherapy.关键词
非小细胞肺癌/参麦注射液/生存期/回顾性研究/倾向性评分匹配/免疫治疗Key words
non-small cell lung cancer/Shenmai injection/survival time/retrospective study/propensity score matching/immunotherapy分类
医药卫生引用本文复制引用
秦磊,张晓春..参麦注射液对非小细胞肺癌生存期影响的回顾性研究[J].湖南中医杂志,2025,41(7):15-20,6.基金项目
江苏省第四批名老中医药专家传承工作室建设项目(苏中医科教[2021]7号) （苏中医科教[2021]7号）
国家重点研发计划"中医药现代化研究"重点专项(2018YFC1705102) （2018YFC1705102）
